13,14-Dihydro-15-keto-PGE2

Description

Description of 13,14-Dihydro-15-keto-PGE2 with associated disease summary

Dihydroprostaglandin E2 (PGEM) is a downstream product of arachidonic acid and prostaglandins G2 (PGG2) in eicosanoid biosynthetic pathways (Pediatr Pulmonol. (2013)). It can be detected using LC-MS/MS and GC-MS method. The concentrations of EBC PGEM in asthmatic patients are significantly higher than the healthy control (Pediatr Pulmonol. (2013), J Allergy Clin Immunol. (2011)). Description of disease(s) related to Dihydroprostaglandin E2 (PGEM):

Disease summary

Asthma

The concentrations of EBC PGEM in asthmatic patients are significantly higher than the healthy control (Pediatr Pulmonol. (2013), J Allergy Clin Immunol. (2011)).

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 13,14-Dihydro-15-keto-PGE2 is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91
Aspirin Sensitive Asthma	MeSH: Asthma, Aspirin-Induced Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010 Link to MeSH Database: D055963	2

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 13,14-Dihydro-15-keto-PGE2. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 13,14-Dihydro-15-keto-PGE2. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 13,14-Dihydro-15-keto-PGE2. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 13,14-Dihydro-15-keto-PGE2. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₂₀H₃₂O₅
Mass	352.471
Synonyms	PGEM 13,14-Dihydro-15-keto-PGE2 15-Keto-13,14-dihydro-PGE2 15-keto-13,14-dihydroprostaglandin E2 13,14-Dihydro-15-ketoprostaglandin E2 363-23-5 KH(2)PGE(2) 13,14-dihydro-15-keto-Prostaglandin E2 9,15-dioxo-11R-hydroxy-5Z-prostenoic acid PGE2 13,14-dihydro 13,14-dihydro-15-oxo-prostaglandin E2 13,14-dihydro-15-keto Prostaglandin E2 (5Z)-(15S)-11alpha-Hydroxy-9,15-dioxoprostanoate dhk-PGE2 AC1NQXGW (5Z)-11alpha-hydroxy-9,15-dioxoprost-5-enoic acid SCHEMBL13958223 BDBM82093 CHEBI:15550 HMDB02776
PubChem CID	5280711