Prostaglandin F2

Description

Description of Prostaglandin F2 with associated disease summary

Prostaglandin F2 (PGF2a) is a downstream product of arachidonic acid and prostaglandins G2 (PGG2) in eicosanoid biosynthetic pathways (Pediatr Pulmonol. (2013)). It can be detected using GC-MS method. The concentrations of EBC PGF2a in asthmatic patients are significantly higher than the healthy control (J Allergy Clin Immunol. (2011)). Description of disease(s) related to Prostaglandin F2 (PGF2a):

Disease summary

Asthma

The concentrations of EBC PGF2a in asthmatic patients are significantly higher than the healthy control (J Allergy Clin Immunol. (2011)).

Summary of extracted biomedical information

Associated references with human 4

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
Lipid peroxidation and plasma antioxidant micronutrients in Crohn disease.	Am. J. Clin. Nutr.	2001	BE. Wendland, E. Aghdassi, C. Tam, J. Carrrier, AH. Steinhart, SL. Wolman, D. Baron, JP. Allard Am. J. Clin. Nutr. 2001 Aug;74(2):259-64. PubMed:11470730
Differential uptake and catabolism of prostaglandin (PG)E(2) versus PGF(2alpha) in the sheep choroid plexus during development.	Brain Res. Dev. Brain Res.	2000	N. Krunic, SL. Adamson, F. Coceani Brain Res. Dev. Brain Res. 2000 Jan;119(1):11-9. PubMed:10648868
Prostaglandins E2 and F2alpha reduce exhaled nitric oxide in normal and asthmatic subjects irrespective of airway caliber changes.	Am. J. Respir. Crit. Care Med.	1998	SA. Kharitonov, MA. Sapienza, PJ. Barnes, KF. Chung Am. J. Respir. Crit. Care Med. 1998 Nov;158(5 Pt 1):1374-8. PubMed:9817681
Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs.	Thorax	1990	G. Nichol, A. Nix, PJ. Barnes, KF. Chung Thorax 1990 Sep;45(9):694-8. PubMed:2145656

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Prostaglandin F2 is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91
Aspirin Sensitive Asthma	MeSH: Asthma, Aspirin-Induced Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010 Link to MeSH Database: D055963	2

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 4 associated references with Prostaglandin F2. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 4 associated references with Prostaglandin F2. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 4 associated references with Prostaglandin F2. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 4 associated references with Prostaglandin F2. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₂₀H₃₄O₅
Mass	354.487
Synonyms	PGF2.alpha. Prostaglandin F2.alpha. Prostaremon F Prostin F2.alpha. MolPort-039-343-870 PXGPLTODNUVGFL-ZQDYKODVSA-N (E,Z)-(1R,2R,3R,5S)-7-[3,5-Dihydroxy-2-[(3S)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic acid STL483413 L000480 (5Z,13E)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]- (5Z,9.alpha.,11.alpha.,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic acid (Z)-7-[2-(3-Hydroxy-1-octenyl)-3,5-dihydroxycyclopentyl]-5-heptenoic acid Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9.alpha.,11.alpha.,13E,15S)- 5-Heptenoic acid, 7-[3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-, [1R-[1.alpha.(Z),2.beta.(S*,E),3.alpha.,5.alpha.]]-
PubChem CID	44208919