1,3-xylene

Summary of extracted biomedical information

1,3-xylene is associated with abnormalities such as Dermo- and Roger's disease. The involved biomedical functions are known as Cell Survival, catalase activity, Adjudication, Inflammation and Synthesis. 1,3-xylene is associated with 3-xylene, Toluene, Sulfhydryl Compounds and Bromides.
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Associated references with human 5

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Journal Year Authors & PubMed Link
Evaluation and modeling of the impact of coexposures to VOC mixtures on urinary biomarkers. Inhal Toxicol 2016 A. Marchand, R. Aranda-Rodriguez, R. Tardif, A. Nong, S. Haddad
Inhal Toxicol 2016 ;28(6):260-73. PubMed:27053005
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Surface acoustic wave (SAW) microsensor array for measuring VOCs in drinking water. J Environ Monit 2006 WA. Groves, AB. Grey, PT. O'Shaughnessy
J Environ Monit 2006 Sep;8(9):932-41. PubMed:16951753
Exposure to volatile organic compounds in residences adjacent to dyeing industrial complex. Int Arch Occup Environ Health 2004 WK. Jo, JW. Lee, DC. Shin
Int Arch Occup Environ Health 2004 Feb;77(2):113-20. PubMed:14648131
Secretion of proinflammatory eicosanoid-like substances precedes allergen release from pollen grains in the initiation of allergic sensitization. Int. Arch. Allergy Immunol. H. Behrendt, A. Kasche, C. Ebner von Eschenbach, U. Risse, J. Huss-Marp, J. Ring
Int. Arch. Allergy Immunol. 2001 Jan-Mar;124(1-3):121-5. PubMed:11306946

Associated curated diseases 0

No curated diseases are identified in current reference collection.

Associated abnormalities 2

Concept Name External ID Weighted Score Hits References
Dermo- 932.41 6
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.
  2. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
Roger's disease 662.0 3
  1. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.

Associated chemicals 4

Concept Name External ID Definition Weighted Score Hits References
3-xylene 935.83 13
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.
  2. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
  3. The use of permeation tube device and the development of empirical formula for accurate permeation rate.
    J. Susaya, KH. Kim, JW. Cho, D. Parker (2011) J Chromatogr A
  4. Volatile organic compounds (VOCs) in surface coating materials: Their compositions and potential as an alternative fuel.
    TV. Dinh, IY. Choi, YS. Son, KY. Song, Y. Sunwoo, JC. Kim (2016) J. Environ. Manage.
Toluene CHEBI:17578 1000.0 5
  1. The use of permeation tube device and the development of empirical formula for accurate permeation rate.
    J. Susaya, KH. Kim, JW. Cho, D. Parker (2011) J Chromatogr A
  2. Volatile organic compounds (VOCs) in surface coating materials: Their compositions and potential as an alternative fuel.
    TV. Dinh, IY. Choi, YS. Son, KY. Song, Y. Sunwoo, JC. Kim (2016) J. Environ. Manage.
Sulfhydryl Compounds 588.05 3
  1. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
Bromides 825.0 1
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.

Associated functions 8

Concept Name External ID Definition Weighted Score Hits References
Cell Survival 1000.0 6
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.
  2. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
catalase activity GO:0004096 973.33 3
  1. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
Adjudication 1000.0 2
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.
  2. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
Inflammation 1000.0 1
  1. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
Synthesis 930.5 1
  1. The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents.
    CA. Coleman, BE. Hull, JN. McDougal, JV. Rogers (2003) Toxicol. Lett.
Skin Absorption 1000.0 1
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.
Analyte 991.43 1
  1. The use of permeation tube device and the development of empirical formula for accurate permeation rate.
    J. Susaya, KH. Kim, JW. Cho, D. Parker (2011) J Chromatogr A
Pressure- physical agent 666.67 1
  1. Improved method for in vitro assessment of dermal toxicity for volatile organic chemicals.
    JV. Rogers, JN. McDougal (2002) Toxicol. Lett.

Associated genes 0

No associated genes are detected in current reference collection.

There are 5 associated references with 1,3-xylene. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C8H10
Mass 106.168
Synonyms M-XYLENE
1,3-Dimethylbenzene
1,3-Xylene
108-38-3
m-Xylol
meta-Xylene
m-Dimethylbenzene
m-Methyltoluene
3-Xylene
Benzene, 1,3-dimethyl-
1,3-Dimethylbenzol
Santosol 150
m-Xylene, benzylated
m-Xylenes
Xylene, m-
2,4-Xylene
Benzene, m-dimethyl-
1,3-Dimethylbenzene, benzylated
UNII-O9XS864HTE
Benzene, 1,3-dimethyl-, benzylated
NSC 61769
CCRIS 907
HSDB 135
IVSZLXZYQVIEFR-UHFFFAOYSA-N
EINECS 203-576-3
EINECS 272-684-0
O9XS864HTE
AI3-08916
CHEMBL286727
CHEBI:28488
Xylol, Dimethylbenzene
DSSTox_CID_1446
DSSTox_RID_78091
DSSTox_GSID_26298
Naphtha Solvent from Coal Tar
Benzylated m-xylene
CAS-108-38-3
metaxylene
Xylene, mixed isomers
META XYLENE
m-Xylene [UN1307] [Flammable liquid]
AC1L1PVL
bmse000554
Xylenes Reagent Grade ACS
EC 203-576-3
AC1Q2QZ7
DSSTox_RID_76162
DSSTox_GSID_21446
KSC492A9P
m-Xylene, analytical standard
BENZENE,1,3-DIMETHYL
m-Xylene, 99% 100ml
ACMC-1C123
WLN: 1R C1
m-Xylene, anhydrous, >=99%
DTXSID6026298
m-Xylene, for synthesis, 99%
CTK3J2097
KS-00000VPL
m-Xylene (1,3-Dimethylbenzene)
MolPort-003-926-319
ZINC968281
m-Xylene, ReagentPlus(R), 99%
NSC61769
m-Xylene 10 microg/mL in Methanol
Tox21_200292
Tox21_202056
Tox21_303203
BDBM50008556
LS-459
MFCD00008536
NSC-61769
STL268867
m-Xylene 100 microg/mL in Methanol
AKOS000121123
MCULE-9376558510
RL00363
RTR-033016
TRA0080357
m-Xylene [UN1307] [Flammable liquid]
NCGC00091711-01
NCGC00091711-02
NCGC00091711-03
NCGC00257052-01
NCGC00257846-01
NCGC00259605-01
AN-22508
CJ-04648
KB-55124
LS-29889
m-Xylene, SAJ first grade, >=98.5%
ZB015547
CAS-1330-20-7
TR-033016
FT-0629041
S0648
m-Xylene, puriss. p.a., >=99.0% (GC)
C07208
28307-EP2280005A1
28307-EP2289884A1
28307-EP2301536A1
28307-EP2301538A1
28307-EP2301923A1
28307-EP2301930A1
28307-EP2309584A1
28307-EP2311455A1
28307-EP2314577A1
28307-EP2380568A1
I01-6934
J-503933
F1908-0174
Xylenes, mixture of isomers, ACS, 98.5% min. 500ml
InChI=1/C8H10/c1-7-4-3-5-8(2)6-7/h3-6H,1-2H
m-Xylene, Pharmaceutical Secondary Standard
Certified Reference Material
Xylene mixture (50.31% m-xylene, 26.9% o-xylene, 22.24% p-xylene)
PubChem CID 7929