5-HETE

Description

Description of 5-HETE with associated disease summary

5-hydroxyeicosatetraenoic acid (5-HETE), an intermediate metabolite of arachidonic acid (AA), is generated by 5-lipoxygenase (5-LOX) in eicosanoid biosynthetic pathways. The level of eicosanoid in exhaled breath condensate (EBC) is usually measured by gas chromatography/mass spectrometry (GC-MS) or high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) or both. The measurement of 5-HETE in EBC helps to detect the alterations in subjects with and without asthma, and evenly, in asthmatic subjects with and without aspirin hypersensitivity. Higher levels of 5-HETE were observed in EBC and activated whole blood samples of asthmatic patients, which allowed accurate discrimination between asthmatic and healthy subjects (Glowacka, Jedynak-Wasowicz et al. 2013). A significant increase of 5-HETE level in asthmatic patients makes 5-HETE be an exhaled marker of asthmatic inflammation. Description of disease(s) related to 5-hydroxyeicosatetraenoic acid (5-HETE):

Asthma

The level of 5-HETE in EBC was significantly higher in asthmatic children, compared to the level in healthy children.

Asthma, Aspirin-Induced

Subjects with asthma had significant increased level of 5-HETE in EBC as compared to healthy control subjects. Before bronchial aspirin challenge on subjects with asthma, the baseline level of 5-HETE in EBC was significantly higher in aspirin-induced asthma (AIA) group than in aspirin-tolerant asthma (ATA) group. After aspirin administration, EBC level of 5-HETE had no significant change in AIA and ATA groups.

Summary of extracted biomedical information

Associated references with human 0

Associated curated diseases 2

Associated disease mapping

Mapping of all associated diseases to 5-HETE is displayed in red.

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 5-HETE. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 5-HETE. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 5-HETE. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 5-HETE. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information