4-Isopropenyltoluene

Description

Description of 4-Isopropenyltoluene with associated disease summary

Early diagnosis and treatment of pulmonary arterial hypertension (PAH) may be made possible by the exploration of novel quantifiable biomarkers. ( PLoS One. (2014) ) Similarly, certain individuals are susceptible to high altitude pulmonary edema (HAPE); early diagnosis may be favorable as well, as the ability to identify individuals at risk of HAPE is currently very poor. ( J Breath Res. (2015) ) One study collected exhaled breath condensate (EBC) from 30-age-matched normal healthy individuals and 27 idiopathic pulmonary arterial hypertension (IPAH; New York Heart Association functional class III/IV) patients. These EBC samples were analyzed using gas chromatography/mass spectrometry (GC-MS) followed by autoregression, and partial least squares regression (AR/PLSR) analysis, to discriminate between the IPAH and control groups. The result shows 1-methyl-4-(1-methylethenyl)-benzene is a common compound found in both IPAH samples and control samples. ( PLoS One. (2014) ) Another study examined the profile of volatile organic compounds (VOC) in EBC of healthy males with/without a history of HAPE. This study used auto-regression, partial least square regression of whole GC/MS data, and binary logistic regression (BLR) of individual GC peaks. This resulted in variable success. The peak identified as 1-methyl-4-(1-methylethenyl)-benzene was identified in both controls and PAH patients. In addition, other possible chemical structures of 1-methyl-4-(1-methylethenyl)-benzene were proposed. ( J Breath Res. (2015) ) Description of disease(s) related to Benzene, 1-methyl-4-(1-methylethenyl)-:

Disease summary

Idiopathic pulmonary arterial hypertension (IPAH)

The result shows 1-methyl-4-(1-methylethenyl)-benzene is a common compound found in both IPAH samples and control samples. ( PLoS One. (2014) )

High altitude pulmonary edema (HAPE) | high altitude pulmonary oedema (HAPO)

The peak identified as 1-methyl-4-(1-methylethenyl)-benzene was identified in both controls and PAH patients. In addition, other possible chemical structures of 1-methyl-4-(1-methylethenyl)-benzene were proposed. ( J Breath Res. (2015) )

Summary of extracted biomedical information

Associated references with human 1

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
A review of the volatiles from the healthy human body.	J Breath Res	2014	B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe J Breath Res 2014 Mar;8(1):014001. PubMed:24421258

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 4-Isopropenyltoluene is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Acute Mountain Sickness	MeSH: Altitude Sickness Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975) Link to MeSH Database: D000532	2
Idiopathic Pulmonary Arterial Hypertenion	MeSH: Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. Link to MeSH Database: D006976	1

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 1 associated references with 4-Isopropenyltoluene. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 1 associated references with 4-Isopropenyltoluene. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 1 associated references with 4-Isopropenyltoluene. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 1 associated references with 4-Isopropenyltoluene. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₁₀H₁₂
Mass	132.206
Synonyms	1195-32-0 4-Isopropenyltoluene Dehydro-p-cymene 2-P-Tolylpropene 1-Methyl-4-(prop-1-en-2-yl)benzene 4-Methylisopropenylbenzene 2-(P-Methylphenyl)propene BENZENE, 1-METHYL-4-(1-METHYLETHENYL)- 1-Isopropenyl-4-methylbenzene 1-Methyl-4-isopropenylbenzene 1-Methyl-4-(1-methylethenyl)benzene Isopropenyltoluene, p- p,alpha-Dimethylstyrene p-alpha-Dimethylstyrene Methyl-p-isopropenylbenzene UNII-XC8HY3OB86 Styrene, P-alpha-dimethyl- alpha-Methyl-P-methylstyrene 4-Methyl-alpha-methylstyrene NSC 361058
PubChem CID	62385