Nonanal

Description

Description of Nonanal with associated disease summary

Aldehydes are biomarkers of oxidant-induced damage. Nonanal is a saturated aldehyde, one of many known breakdown products of oxidized linoleic acid and arachidonic acid, palmitoleic acid, and oleic. Aldehydes are detectable in exhaled breath condensate (EBC) of children. One study with asthma children vs. control subjects find that nonanal levels are modified during asthma exacerbation and after a 5-day course of therapy with oral prednisone. Nonanal levels were higher in control subjects than in asthma subjects. This led to the speculation of whether this is a result of different membrane cell lipid targets of the reactive oxygen species or different composition in membrane cell phospholipids in lung diseases. Further studies are warranted. ( Am J Respir Crit Care Med. (2003) ) An applied MSPE-HPLC method for successful determination of aldehydes metabolites in EBC was proposed, and tested in EBC samples of healthy controls and lung cancer patients. Under optimal conditions, the peak for nonanal was identified. The nonanal levels in EBC of lung cancer patients were higher than those of healthy controls. This proposed method is an alternative approach for quantifying aldehyde metabolites in complex biological samples ( J Chromatogr A. (2014) ). Description of disease(s) related to Nonanal:

Disease summary

Asthma

Nonanal levels were higher in control subjects than in asthma subjects. This led to the speculation of whether this is a result of different membrane cell lipid targets of the reactive oxygen species or different composition in membrane cell phospholipids in lung diseases. Further studies are warranted. ( Am J Respir Crit Care Med. (2003) )

Lung Cancer

The nonanal levels in EBC of lung cancer patients were higher than those of healthy controls. This proposed method is an alternative approach for quantifying aldehyde metabolites in complex biological samples ( J Chromatogr A. (2014) ).

Summary of extracted biomedical information

Nonanal is associated with nonanal, Butylene Glycols, Butanones and Protons.
Imgsrv

Associated references with human 3

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Reference title

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Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Volatile organic compounds in exhaled breath in a healthy population: effect of tobacco smoking. Arch. Bronconeumol. 2013 JJ. Jareño-Esteban, MÁ. Muñoz-Lucas, B. Carrillo-Aranda, JÁ. Maldonado-Sanz, I. de Granda-Orive, A. Aguilar-Ros, C. Civera-Tejuca, C. Gutiérrez-Ortega, LM. Callol-Sánchez, .
Arch. Bronconeumol. 2013 Nov;49(11):457-61. PubMed:23791244
Symptoms in relation to chemicals and dampness in newly built dwellings. Int Arch Occup Environ Health 2004 Y. Saijo, R. Kishi, F. Sata, Y. Katakura, Y. Urashima, A. Hatakeyama, S. Kobayashi, K. Jin, N. Kurahashi, T. Kondo, YY. Gong, T. Umemura
Int Arch Occup Environ Health 2004 Oct;77(7):461-70. PubMed:15558298

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Nonanal is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Non Small Cell Lung Cancer, Lung Neoplasms MeSH: Lung Neoplasms
Tumors or cancer of the LUNG.
Link to MeSH Database: D008175
4

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C9H18O
Mass 142.242
Synonyms NONANAL
Pelargonaldehyde
1-Nonanal
124-19-6
Nonanaldehyde
Nonyl aldehyde
n-Nonaldehyde
Nonylic aldehyde
Nonylaldehyde
Nonaldehyde
n-Nonanal
1-Nonaldehyde
Nonanoic aldehyde
Pelargonic aldehyde
Aldehyde C-9
1-Nonyl aldehyde
C-9 aldehyde
n-Nonylaldehyde
Nonoic aldehyde
NONYL ALDEHYDE,N-
PubChem CID 31289