Nonanal

Description

Description of Nonanal with associated disease summary

Aldehydes are biomarkers of oxidant-induced damage. Nonanal is a saturated aldehyde, one of many known breakdown products of oxidized linoleic acid and arachidonic acid, palmitoleic acid, and oleic. Aldehydes are detectable in exhaled breath condensate (EBC) of children. One study with asthma children vs. control subjects find that nonanal levels are modified during asthma exacerbation and after a 5-day course of therapy with oral prednisone. Nonanal levels were higher in control subjects than in asthma subjects. This led to the speculation of whether this is a result of different membrane cell lipid targets of the reactive oxygen species or different composition in membrane cell phospholipids in lung diseases. Further studies are warranted. ( Am J Respir Crit Care Med. (2003) ) An applied MSPE-HPLC method for successful determination of aldehydes metabolites in EBC was proposed, and tested in EBC samples of healthy controls and lung cancer patients. Under optimal conditions, the peak for nonanal was identified. The nonanal levels in EBC of lung cancer patients were higher than those of healthy controls. This proposed method is an alternative approach for quantifying aldehyde metabolites in complex biological samples ( J Chromatogr A. (2014) ). Description of disease(s) related to Nonanal:

Disease summary

Asthma

Nonanal levels were higher in control subjects than in asthma subjects. This led to the speculation of whether this is a result of different membrane cell lipid targets of the reactive oxygen species or different composition in membrane cell phospholipids in lung diseases. Further studies are warranted. ( Am J Respir Crit Care Med. (2003) )

Lung Cancer

The nonanal levels in EBC of lung cancer patients were higher than those of healthy controls. This proposed method is an alternative approach for quantifying aldehyde metabolites in complex biological samples ( J Chromatogr A. (2014) ).

Summary of extracted biomedical information

Nonanal is associated with nonanal, Butylene Glycols, Butanones and Protons.

Associated references with human 3

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
A review of the volatiles from the healthy human body.	J Breath Res	2014	B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Volatile organic compounds in exhaled breath in a healthy population: effect of tobacco smoking.	Arch. Bronconeumol.	2013	JJ. Jareño-Esteban, MÁ. Muñoz-Lucas, B. Carrillo-Aranda, JÁ. Maldonado-Sanz, I. de Granda-Orive, A. Aguilar-Ros, C. Civera-Tejuca, C. Gutiérrez-Ortega, LM. Callol-Sánchez, . Arch. Bronconeumol. 2013 Nov;49(11):457-61. PubMed:23791244
Symptoms in relation to chemicals and dampness in newly built dwellings.	Int Arch Occup Environ Health	2004	Y. Saijo, R. Kishi, F. Sata, Y. Katakura, Y. Urashima, A. Hatakeyama, S. Kobayashi, K. Jin, N. Kurahashi, T. Kondo, YY. Gong, T. Umemura Int Arch Occup Environ Health 2004 Oct;77(7):461-70. PubMed:15558298

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Nonanal is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91
Non Small Cell Lung Cancer, Lung Neoplasms	MeSH: Lung Neoplasms Tumors or cancer of the LUNG. Link to MeSH Database: D008175	4

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with Nonanal. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₉H₁₈O
Mass	142.242
Synonyms	NONANAL Pelargonaldehyde 1-Nonanal 124-19-6 Nonanaldehyde Nonyl aldehyde n-Nonaldehyde Nonylic aldehyde Nonylaldehyde Nonaldehyde n-Nonanal 1-Nonaldehyde Nonanoic aldehyde Pelargonic aldehyde Aldehyde C-9 1-Nonyl aldehyde C-9 aldehyde n-Nonylaldehyde Nonoic aldehyde NONYL ALDEHYDE,N-
PubChem CID	31289