Glutathione
Description
Description of glutathione with associated disease summary
Glutathione is a major antioxidant in the
epithelial lining fluid (ELF) of the lungs ( Respir Med. (2008)
). In one study, glutathione levels were higher in the exhaled
breath condensate (EBC) of control subjects than in asthma subjects, as
measured by high-performance liquid chromatography with fluorescence detection
(LC-Fluorescent) ( Am J Respir Crit Care Med.
(2003) ).
The same study also revealed glutathione
levels in asthma subjects rose after oral steroid treatment compared with
pretreatment group, this could be explained by the fact that corticosteroids
have been demonstrated to increase glutathione synthase in both animal models
and in vitro systems ( Am J Respir Crit Care Med.
(2003) ).
Chronic alcoholism is associated with an
elevated risk for pulmonary infection and a 3-fold chance for incidence and
mortality of acute respiratory distress syndrome with critical injury. The role
of glutathione redox balance in pulmonary function and diseased states was
investigated in a study using EBC collected from healthy subjects with or
without a history of alcohol abuse.
Studies reported an alcohol-induced
depletion of glutathione. It was also reported that chronic alcoholism is associated
with elevated oxidation of glutathione ( Respir Med. (2008)
).
Description of disease(s) related to glutathione:
Alcohol abuse
Studies reported an alcohol-induced depletion of glutathione. It was also reported that chronic alcoholism is associated with elevated oxidation of glutathione ( Respir Med. (2008) ).Asthma
One study revealed glutathione levels in asthma subjects rose after oral steroid treatment compared with pretreatment group, this could be explained by the fact that corticosteroids have been demonstrated to increase glutathione synthase in both animal models and in vitro systems ( Am J Respir Crit Care Med. (2003) ).Summary of extracted biomedical information
Glutathione is associated with abnormalities such as Tuberculosis, Lung diseases, Tietze's Syndrome, Respiratory Distress Syndrome, Adult and Rheumatoid Arthritis. The involved biomedical functions are known as acidification, Adjudication, Laser-generated electromagnetic radiation, Proteolysis and hemolysis. The associated genes/proteins with glutathione are GSTP1 gene. Glutathione is associated with eosin maleimide, Carbon, Organic solvent product, 6-iodoacetamidofluorescein and 5-iodoacetamidofluorescein.Associated references with human 19
Download references
Reference title
with link to reference page |
Journal | Year | Authors & PubMed Link |
---|---|---|---|
Sensitive determination of glutathione in biological samples by capillary electrophoresis with green (515 nm) laser-induced fluorescence detection. | J Chromatogr A | 2015 |
J. Hodáková, J. Preisler, F. Foret, P. Kubáň
J Chromatogr A 2015 Apr;1391:102-8. PubMed:25757819 |
Exhaled breath condensate in intubated neonates--a window into the lung's glutathione status. | Respir. Res. | 2014 |
MI. Rosso, S. Roark, E. Taylor, X. Ping, JM. Ward, K. Roche, C. McCracken, LA. Brown, TW. Gauthier
Respir. Res. 2014 Jan;15:1. PubMed:24397246 |
Exhaled breath condensate: a promising source for biomarkers of lung disease. | ScientificWorldJournal | 2012 |
Y. Liang, SM. Yeligar, LA. Brown
ScientificWorldJournal 2012 ;2012:217518. PubMed:23365513 |
Chronic-alcohol-abuse-induced oxidative stress in the development of acute respiratory distress syndrome. | ScientificWorldJournal | 2012 |
Y. Liang, SM. Yeligar, LA. Brown
ScientificWorldJournal 2012 ;2012:740308. PubMed:23346021 |
Genotoxic effects in swimmers exposed to disinfection by-products in indoor swimming pools. | Environ. Health Perspect. | 2010 |
M. Kogevinas, CM. Villanueva, L. Font-Ribera, D. Liviac, M. Bustamante, F. Espinoza, MJ. Nieuwenhuijsen, A. Espinosa, P. Fernandez, DM. DeMarini, JO. Grimalt, T. Grummt, R. Marcos
Environ. Health Perspect. 2010 Nov;118(11):1531-7. PubMed:20833606 |
Current perspectives of oxidative stress and its measurement in chronic obstructive pulmonary disease. | COPD | 2010 |
JL. Lin, PS. Thomas
COPD 2010 Aug;7(4):291-306. PubMed:20673039 |
Chlorobenzene induces oxidative stress in human lung epithelial cells in vitro. | Toxicol. Appl. Pharmacol. | 2010 |
R. Feltens, I. Mögel, C. Röder-Stolinski, JC. Simon, G. Herberth, I. Lehmann
Toxicol. Appl. Pharmacol. 2010 Jan;242(1):100-8. PubMed:19800902 |
Genetic polymorphisms influence the susceptibility of men to sperm DNA damage associated with exposure to air pollution. | Mutat. Res. | 2010 |
J. Rubes, R. Rybar, P. Prinosilova, Z. Veznik, I. Chvatalova, I. Solansky, RJ. Sram
Mutat. Res. 2010 Jan;683(1-2):9-15. PubMed:19800896 |
Moderate altitude but not additional endurance training increases markers of oxidative stress in exhaled breath condensate. | Eur. J. Appl. Physiol. | 2009 |
I. Heinicke, A. Boehler, T. Rechsteiner, A. Bogdanova, W. Jelkmann, M. Hofer, P. Rawlings, OF. Araneda, C. Behn, M. Gassmann, K. Heinicke
Eur. J. Appl. Physiol. 2009 Jul;106(4):599-604. PubMed:19363619 |
Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-kappaB activation. | Toxicol. Appl. Pharmacol. | 2008 |
C. Röder-Stolinski, G. Fischäder, GJ. Oostingh, R. Feltens, F. Kohse, M. von Bergen, N. Mörbt, K. Eder, A. Duschl, I. Lehmann
Toxicol. Appl. Pharmacol. 2008 Sep;231(2):241-7. PubMed:18554678 |
Ambient particulate matter (PM2.5): physicochemical characterization and metabolic activation of the organic fraction in human lung epithelial cells (A549). | Environ. Res. | 2007 |
S. Billet, G. Garçon, Z. Dagher, A. Verdin, F. Ledoux, F. Cazier, D. Courcot, A. Aboukais, P. Shirali
Environ. Res. 2007 Oct;105(2):212-23. PubMed:17462623 |
Reactive oxidant species in asthma. | Curr Opin Pulm Med | 2006 |
JC. Mak, MM. Chan-Yeung
Curr Opin Pulm Med 2006 Jan;12(1):7-11. PubMed:16357572 |
Oxidative stress induction by short time exposure to ozone on THP-1 cells. | Toxicol In Vitro | 2006 |
L. Foucaud, A. Bennasroune, D. Klestadt, P. Laval-Gilly, J. Falla
Toxicol In Vitro 2006 Feb;20(1):101-8. PubMed:16055301 |
Advanced glycation end-products in sickle cell anaemia. | Br. J. Haematol. | 2005 |
SS. Somjee, RP. Warrier, JL. Thomson, J. Ory-Ascani, JM. Hempe
Br. J. Haematol. 2005 Jan;128(1):112-8. PubMed:15606557 |
Estimation of interindividual variation in oxidative metabolism of dichloromethane in human volunteers. | Toxicol. Lett. | 2004 |
LM. Sweeney, CR. Kirman, DA. Morgott, ML. Gargas
Toxicol. Lett. 2004 Dec;154(3):201-16. PubMed:15501612 |
Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues. | Redox Rep. | 2004 |
I. Rahman, SK. Biswas
Redox Rep. 2004 ;9(3):125-43. PubMed:15327743 |
Biomarkers of oxidative stress after controlled human exposure to ozone. | Toxicol. Lett. | 2002 |
M. Corradi, R. Alinovi, M. Goldoni, M. Vettori, G. Folesani, P. Mozzoni, S. Cavazzini, E. Bergamaschi, L. Rossi, A. Mutti
Toxicol. Lett. 2002 Aug;134(1-3):219-25. PubMed:12191881 |
Characterization of non-small-cell lung cancer cell lines established before and after chemotherapy. | Lung Cancer | 2002 |
H. Kawai, K. Kiura, M. Tabata, T. Yoshino, I. Takata, A. Hiraki, K. Chikamori, H. Ueoka, M. Tanimoto, M. Harada
Lung Cancer 2002 Mar;35(3):305-14. PubMed:11844606 |
Microscopic modeling of NO and S-nitrosoglutathione kinetics and transport in human airways. | J. Appl. Physiol. | 2001 |
HY. Shin, SC. George
J. Appl. Physiol. 2001 Mar;90(3):777-88. PubMed:11181583 |
Associated curated diseases 1
Download diseasesAssociated disease mapping
Mapping of all associated diseases to glutathione is displayed in red.
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
---|---|---|
Asthma |
MeSH:
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and
intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of
airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
|
91 |
Associated abnormalities 3
Concept Name | External ID | Weighted Score | Hits | References | |
Tuberculosis | 1000.0 | 1 |
|
||
Lung diseases | 1000.0 | 1 |
|
||
Tietze's Syndrome | ICD9-CM:733.6 | 676.47 | 1 |
|
Associated chemicals 6
Associated functions 11
Associated genes 1
Concept Name | External ID | Definition | Weighted Score | Hits | References | |
GSTP1 gene | EntrezGene:2950 | 678.5 | 1 |
|
NCBI Entrez Crosslinks
Chemical Information
Formula | C10H17N3O6S |
Mass | 307.321 |
Synonyms | glutathione 70-18-8 L-Glutathione Glutathion reduced glutathione Glutathione-SH Glutinal Isethion Deltathione Glutide Neuthion Tathion Copren Tathione Triptide Ledac Glutatione Glutatiol GSH Panaron |
PubChem CID | 124886 |