Description of adenosine with associated disease summary
AsthmaA metabolomic profiling of EBC analysis using Bidirectional-Orthogonal Projections to Latent Structures-Discriminant (O2PLS-DA) method was constructed for distinguishing both between severe asthma cases and healthy children and between severe and nonsevere asthmatic children. The chemical structures of adenosine, retinoic acid, and vitamin D have been found to be relevant characteristics that could clearly discriminate different biochemical-metabolic profiles in between non-severe/severe asthmatic and healthy children. The Adenosine measurement in EBC is a confident biomarker for monitoring airway inflammation in patients with asthma (Allergy. (2013)). Another study shows the elevated adenosine level in steroid-naïve asthmatic patients compared with healthy control but no significant difference of adenosine level between the steroid-treated asthmatic patients and healthy control (Eur Respir J. (2002)).
BronchoconstrictionSignificant increase in the adenosine concentration in EBC determined by HPLC and can be found in patients with physically exercise-induced bronchoconstriction (airway obstruction) compared to the healthy controls (Eur Respir J. (2005) ).
Cystic FibrosisThe EBC concentration ratio of purine adenosine (Ado) and adenosine monophosphate (AMP) has strong correlation with the children (<3 years old) with cystic fibrosis or other lung diseases and can be used as a less invasive methods for assessment of airway inflammation (Pediatr Pulmonol. (2013)).
Rhinitis, Allergic, PerennialPatients with allergic rhinitis that may initiate inflammation in the lower airways results in an increased adenosine levels in EBC and also correlates with an increased in nasal nitric oxide (NO) levels. Rhinitis patients with no asthma may also have the symptoms of subclinical inflammation in their lower airways (Clin Exp Allergy. (2006)).
Summary of extracted biomedical informationAdenosine is associated with inorganic phosphate.
Associated references with human 7Download references
with link to reference page
|Journal||Year||Authors & PubMed Link|
|Human exhaled breath analysis.||Ann. Allergy Asthma Immunol.||2011||
Ann. Allergy Asthma Immunol. 2011 Jun;106(6):451-6; quiz 457. PubMed:21624743
|Exhaled breath condensate in patients with asthma: implications for application in clinical practice.||Clin. Exp. Allergy||2008||
K. Kostikas, A. Koutsokera, S. Papiris, KI. Gourgoulianis, S. Loukides
Clin. Exp. Allergy 2008 Apr;38(4):557-65. PubMed:18352973
|Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.||Eur. Respir. J.||2008||
RA. Brown, GW. Clarke, CL. Ledbetter, MJ. Hurle, JC. Denyer, DE. Simcock, JE. Coote, TJ. Savage, RD. Murdoch, CP. Page, D. Spina, BJ. O'Connor
Eur. Respir. J. 2008 Feb;31(2):311-9. PubMed:17959644
|Endothelin-1 in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction.||Respir. Res.||2007||
Z. Zietkowski, R. Skiepko, MM. Tomasiak, A. Bodzenta-Lukaszyk
Respir. Res. 2007 Oct;8:76. PubMed:17973986
|Exhaled breath condensate: methodological recommendations and unresolved questions.||Eur. Respir. J.||2005||
I. Horváth, J. Hunt, PJ. Barnes, K. Alving, A. Antczak, E. Baraldi, G. Becher, WJ. van Beurden, M. Corradi, R. Dekhuijzen, RA. Dweik, T. Dwyer, R. Effros, S. Erzurum, B. Gaston, C. Gessner, A. Greening, LP. Ho, J. Hohlfeld, Q. Jöbsis, D. Laskowski, S. Loukides, D. Marlin, P. Montuschi, AC. Olin, AE. Redington, P. Reinhold, EL. van Rensen, I. Rubinstein, P. Silkoff, K. Toren, G. Vass, C. Vogelberg, H. Wirtz, .
Eur. Respir. J. 2005 Sep;26(3):523-48. PubMed:16135737
|Adenosine levels in the exhaled breath condensate: a potential surrogate marker of airway inflammation.||Eur. Respir. J.||2003||
L. Spicuzza, GU. Di Maria, R. Polosa
Eur. Respir. J. 2003 Aug;22(2):392; author reply 392-3. PubMed:12952279
|The case for a role for adenosine in asthma: almost convincing?||Curr Opin Pharmacol||2003||
Curr Opin Pharmacol 2003 Jun;3(3):264-9. PubMed:12810190
Associated curated diseases 4Download diseases
Associated disease mapping
Mapping of all associated diseases to adenosine is displayed in red.
with link to disease page
Description of MeSH term
with link to MeSH Database
|Number of references|
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Link to MeSH Database: D001249
|Allergic Rhinitis With Asthma||
Rhinitis, Allergic, Perennial
Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc. Year introduced: 1980Link to MeSH Database: D012221
|Exercise Induced Bronchoconstriction||
Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention. Year introduced: 1991Link to MeSH Database: D016084
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967Link to MeSH Database: D003550
Associated abnormalities 0
No associated abnormalities are detected in current reference collection.
There are 7 associated references with adenosine. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.
Associated chemicals 0
No associated chemicals are detected in current reference collection.
There are 7 associated references with adenosine. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.
Associated functions 0
No associated functions are detected in current reference collection.
There are 7 associated references with adenosine. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 7 associated references with adenosine. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
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