2,5-Dimethylbenzaldehyde

Description

Description of 2,5-Dimethylbenzaldehyde with associated disease summary

Certain individuals are susceptible to high altitude pulmonary edema (HAPE); the ability to identify individuals at risk of HAPE is currently very poor. Analysis of exhaled breath condensate (EBC) may present a favorable non-invasive method. A study examined the profile of volatile organic compounds (VOC) in EBC of healthy males with/without a history of HAPE. This study used auto-regression, partial least square regression of whole GC/MS data, and binary logistic regression (BLR) of individual GC peaks. This resulted in variable success. The peak for dimethylbenzaldehyde was identified, and the study suggests it may be a potential discriminatory marker for patients with HAPE history. Further studies are needed to establish mechanistic details of formation and biological basis for the detected biomarker compounds ( J Breath Res. (2015) ). Description of disease(s) related to Benzaldehyde, 2,5-dimethyl-

Disease summary

High altitude pulmonary edema (HAPE) | High altitude pulmonary oedema (HAPO)

The peak for dimethylbenzaldehyde was identified, and the study suggests it may be a potential discriminatory marker for patients with HAPE history ( J Breath Res. (2015) ).

Summary of extracted biomedical information

Imgsrv

Associated references with human 1

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Reference title

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Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 2,5-Dimethylbenzaldehyde is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

with link to MeSH Database

Number of references
Acute Mountain Sickness MeSH: Altitude Sickness
Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975)
Link to MeSH Database: D000532
2
Idiopathic Pulmonary Arterial Hypertenion MeSH: Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Link to MeSH Database: D006976
1

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 1 associated references with 2,5-Dimethylbenzaldehyde. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 1 associated references with 2,5-Dimethylbenzaldehyde. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 1 associated references with 2,5-Dimethylbenzaldehyde. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 1 associated references with 2,5-Dimethylbenzaldehyde. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C9H10O
Mass 134.178
Synonyms 2,5-DIMETHYLBENZALDEHYDE
5779-94-2
Benzaldehyde, 2,5-dimethyl-
Isoxylaldehyde
2,5-DiMethyl-Benzaldehyde
SMUVABOERCFKRW-UHFFFAOYSA-N
SBB008435
FR-2051
AK135217
W-105442
UNII-6M224X1615
EINECS 227-303-2
ZINC02012003
ACMC-20aoaf
PubChem1474
AC1L2JKQ
AC1Q2IHC
AC1Q6Q3D
Benzaldehyde,2,5-dimethyl-
SCHEMBL268706
PubChem CID 22015