D-Glucose

Description

Description of D-Glucose with associated disease summary

In humans, glucose concentrations are normally elevated by inflammation or hyperglycemia. Elevated bronchial glucose is associated with increased respiratory infection in intensive care patients. To determine the effects of hyperglycemia and lung disease on lung glucose concentrations, one study recruited healthy volunteers and patients with Type 1 or 2 diabetes mellitus, all nonsmokers and with no history of lung diseases. G lucose was measured by chromatography with pulsed amperometric detection. This study finds that breath glucose in healthy volunteers was reproducible and unaffected by changes in salivary glucose. Breath glucose was elevated in diabetic patients without lung disease in proportion to hyperglycemia. Breath glucose was elevated more than expected for blood glucose in cystic fibrosis (CF) patients and in CF-related diabetes. The noninvasive method for glucose detection simplified the diagnosis for patients. Glucose as a biomarker will aid in the investigations of elevated respiratory fluid glucose in human lung diseases ( J Appl Physiol (1985).(2007) ). Description of disease(s) related to glucose:

Diabetes Mellitus

Breath glucose was elevated in diabetic patients without lung disease in proportion to hyperglycemia (J Appl Physiol (1985).(2007) ).

Cystic Fibrosis

Breath glucose was elevated in diabetic patients without lung disease in proportion to hyperglycemia. Breath glucose was elevated more than expected for blood glucose in cystic fibrosis (CF) patients and in CF-related diabetes (J Appl Physiol (1985).(2007) ).

Summary of extracted biomedical information

D-glucose is associated with abnormalities such as Diabetes, Obesity, Hyperinsulinism, Dyslipidemias and Obesity, Morbid. The involved biomedical functions are known as insulin sensitivity, glucose metabolism, Insulin Resistance, Infiltration and GLUCOSE TOLERANCE. D-glucose is associated with Blood Glucose.
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Associated references with human 15

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Journal Year Authors & PubMed Link
Clinical assessment of the lag-time and tmax of pellets with controlled release of glucose: in vitro/in vivo comparison using 13 C-breath test. Biopharm Drug Dispos 2017 D. Neumann, J. Muselík, D. Sabadková, S. Pavloková, J. Špirková, A. Franc
Biopharm Drug Dispos 2017 Nov;38(8):458-463. PubMed:28670738
Breath gas monitoring during a glucose challenge by a combined PTR-QMS/GC×GC-TOFMS approach for the verification of potential volatile biomarkers. J Breath Res 2016 B. Gruber, S. Keller, T. Groeger, G. Matuschek, W. Szymczak, R. Zimmermann
J Breath Res 2016 06;10(3):036003. PubMed:27341456
Insulin sensitivity index (ISI0, 120) potentially linked to carbon isotopes of breath CO2 for pre-diabetes and type 2 diabetes. Sci Rep 2015 C. Ghosh, P. Mukhopadhyay, S. Ghosh, M. Pradhan
Sci Rep 2015 Jul;5:11959. PubMed:26148706
Non-invasive 13C-glucose breath test using residual gas analyzer-mass spectrometry: a novel tool for screening individuals with pre-diabetes and type 2 diabetes. J Breath Res 2014 C. Ghosh, A. Maity, GD. Banik, S. Som, A. Chakraborty, C. Selvan, S. Ghosh, B. Ghosh, S. Chowdhury, M. Pradhan
J Breath Res 2014 Sep;8(3):036001. PubMed:24946152
Current understandings and perspectives on non-cancer health effects of benzene: a global concern. Toxicol. Appl. Pharmacol. 2014 H. Bahadar, S. Mostafalou, M. Abdollahi
Toxicol. Appl. Pharmacol. 2014 Apr;276(2):83-94. PubMed:24589379
[13C]glucose breath testing provides a noninvasive measure of insulin resistance: calibration analyses against clamp studies. Diabetes Technol. Ther. 2014 M. Hussain, M. Jangorbhani, S. Schuette, RV. Considine, RL. Chisholm, KJ. Mather
Diabetes Technol. Ther. 2014 Feb;16(2):102-12. PubMed:24116833
Noninvasive monitoring of glucose levels: is exhaled breath the answer? J Diabetes Sci Technol 2012 K. Roberts, A. Jaffe, C. Verge, PS. Thomas
J Diabetes Sci Technol 2012 May;6(3):659-64. PubMed:22768898
Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia. BMC Med Res Methodol 2010 DZ. Levett, DS. Martin, MH. Wilson, K. Mitchell, S. Dhillon, F. Rigat, HE. Montgomery, MG. Mythen, MP. Grocott, .
BMC Med Res Methodol 2010 Oct;10:98. PubMed:20964858
Aluminum gallium nitride (GaN)/GaN high electron mobility transistor-based sensors for glucose detection in exhaled breath condensate. J Diabetes Sci Technol 2010 BH. Chu, BS. Kang, SC. Hung, KH. Chen, F. Ren, A. Sciullo, BP. Gila, SJ. Pearton
J Diabetes Sci Technol 2010 Jan;4(1):171-9. PubMed:20167182
Nitric oxide gas phase release in human small airway epithelial cells. Respir. Res. 2009 J. Jiang, N. Malavia, V. Suresh, SC. George
Respir. Res. 2009 Jan;10:3. PubMed:19152703
Influenza virus in human exhaled breath: an observational study. PLoS ONE 2008 P. Fabian, JJ. McDevitt, WH. DeHaan, RO. Fung, BJ. Cowling, KH. Chan, GM. Leung, DK. Milton
PLoS ONE 2008 Jul;3(7):e2691. PubMed:18628983
NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines. Br. J. Cancer 2006 Y. Yang, T. Ikezoe, C. Nishioka, K. Bandobashi, T. Takeuchi, Y. Adachi, M. Kobayashi, S. Takeuchi, HP. Koeffler, H. Taguchi
Br. J. Cancer 2006 Dec;95(12):1653-62. PubMed:17133272
Exhaled breath condensates: a potential novel technique for detecting aspiration. Am. J. Med. 2003 RM. Effros, M. Bosbous, B. Foss, R. Shaker, J. Biller
Am. J. Med. 2003 Aug;115 Suppl 3A:137S-143S. PubMed:12928090
Microbiological and fermentation characteristics of togwa, a Tanzanian fermented food. Int. J. Food Microbiol. 2003 JK. Mugula, SA. Nnko, JA. Narvhus, T. Sørhaug
Int. J. Food Microbiol. 2003 Feb;80(3):187-99. PubMed:12423921
Effect of codeine and loperamide on upper intestinal transit and absorption in normal subjects and patients with postvagotomy diarrhoea. Gut 1988 JD. O'Brien, DG. Thompson, A. McIntyre, WR. Burnham, E. Walker
Gut 1988 Mar;29(3):312-8. PubMed:3356363

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to D-Glucose is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

with link to MeSH Database

Number of references
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Cystic Fibrosis Related Diabetes (Cfrd) MeSH: Diabetes Mellitus
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Link to MeSH Database: D003920
1

Associated abnormalities 5

Concept Name External ID Weighted Score Hits References
Obesity 817.89 3
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Diabetes 939.9 3
  1. Equine laminitis: comparative histopathology 48 hours after experimental induction with insulin or alimentary oligofructose in standardbred horses.
    MA. de Laat, AW. van Eps, CM. McGowan, MN. Sillence, CC. Pollitt (2011) J. Comp. Pathol.
  2. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Hyperinsulinism 1000.0 2
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Dyslipidemias 961.54 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Cardiovascular Diseases ICD9-CM:429.2 978.26 1
  1. Equine laminitis: comparative histopathology 48 hours after experimental induction with insulin or alimentary oligofructose in standardbred horses.
    MA. de Laat, AW. van Eps, CM. McGowan, MN. Sillence, CC. Pollitt (2011) J. Comp. Pathol.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 15 associated references with D-Glucose. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 11

Concept Name External ID Definition Weighted Score Hits References
glucose metabolism 937.17 3
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Insulin Resistance 1000.0 2
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
insulin sensitivity 917.13 2
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Infiltration 936.0 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
GLUCOSE TOLERANCE 967.0 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Blood Circulation GO:0008015 823.53 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Functional disorder 733.47 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
uptake 882.0 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
glucose uptake 1000.0 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Hepatic Metabolism 1000.0 1
  1. Fabrication of a biofuel cell improved by the π-conjugated electron pathway effect induced from a new enzyme catalyst employing terephthalaldehyde.
    Y. Chung, KH. Hyun, Y. Kwon (2016) Nanoscale
Complication 985.67 1
  1. Equine laminitis: comparative histopathology 48 hours after experimental induction with insulin or alimentary oligofructose in standardbred horses.
    MA. de Laat, AW. van Eps, CM. McGowan, MN. Sillence, CC. Pollitt (2011) J. Comp. Pathol.

Associated genes 0

No associated genes are detected in current reference collection.

There are 15 associated references with D-Glucose. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C6H12O6
Mass 180.156
Synonyms D-Glucose
D-Glucopyranose
Glucose
Glucopyranose
Grape sugar
D-Glc
Glucodin
Meritose
Clintose L
CPC hydrate
Roferose ST
Clearsweet 95
Staleydex 95M
D-Glcp
CHEBI:4167
2280-44-6
Glucopyranoside
D-Glucopyranoside
Glucopyranose, D-
Glc
PubChem CID 5793