DL-Tryptophan

Description

Description of DL-Tryptophan with associated disease summary

Levels of systemic tryptophan and kynurenine in serum have associations with the severity of asthma exacerbation induced by rhinovirus. Indoleamine 2,3-dioxygenase (IDO) is an antiviral tryptophan-catabolizing enzyme. IDO has antiviral and immunosuppressive properties, so IDO and tryptophan play important roles in the allergic airway inflammation. Level of systemic tryptophan in serum of asthma individuals is higher than healthy individuals. But level of local tryptophan in EBC (Exhaled Breath Condensate) is not different between asthma group and healthy group. Measurement of systemic tryptophan and the downstream product could be seen as a prognostic factor of allergic asthma with rhinovirus infection. Tryptophan was measured by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) (Thorax (2013)). Description of disease(s) related to Tryptophan:

Disease summary

Asthma

Systemic tryptophan in serum of allergic asthma subjects is higher than healthy subjects. Local tryptophan in EBC is not different between asthma and healthy subjects (Thorax (2013)).

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to DL-Tryptophan is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with DL-Tryptophan. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with DL-Tryptophan. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with DL-Tryptophan. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with DL-Tryptophan. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₁₁H₁₂N₂O₂
Mass	204.229
Synonyms	DL-Tryptophan 54-12-6 DL-Trytophane DL-Trytophan 2-amino-3-(1H-indol-3-yl)propanoic acid Racemic Tryptophan (+-)-Tryptophan DL-tryptophane tryptophan(.) NSC 13118 CCRIS 719 DL-Tryptophan, 99% DL-3beta-Indolylalanine TRYPTOPHAN, DL- EINECS 200-194-9 DL-alpha-Amino-3-indolepropionic acid AI3-24395 CHEBI:27897 QIVBCDIJIAJPQS-UHFFFAOYSA-N NSC13119
PubChem CID	1148