1,4-dichlorobenzene

Summary of extracted biomedical information

1,4-dichlorobenzene is associated with abnormalities such as Tangier Disease. The involved biomedical functions are known as Analyte, dose-response relationship and Inspiration function. 1,4-dichlorobenzene is associated with 4-xylene, Toluene, Butadiene, chlorobenzene and Naphthalene.
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Associated references with human 22

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Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China. Environ Int 2014 Z. Du, J. Mo, Y. Zhang
Environ Int 2014 Dec;73:33-45. PubMed:25090575
Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative sample. Sci. Total Environ. 2012 C. Jia, X. Yu, W. Masiak
Sci. Total Environ. 2012 Mar;419:225-32. PubMed:22285084
GC/MS with post-column switching for large volume injection of headspace samples: sensitive determination of volatile organic compounds in human whole blood and urine. Anal. Chem. 2011 K. Watanabe, H. Fujita, K. Hasegawa, K. Gonmori, O. Suzuki
Anal. Chem. 2011 Feb;83(4):1475-9. PubMed:21268608
An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools. Int J Hyg Environ Health 2011 SC. Sofuoglu, G. Aslan, F. Inal, A. Sofuoglu
Int J Hyg Environ Health 2011 Jan;214(1):36-46. PubMed:20833585
Health risk assessment of exposure to selected volatile organic compounds emitted from an integrated iron and steel plant. Inhal Toxicol 2010 EE. Chang, W. Wei-Chi, Z. Li-Xuan, C. Hung-Lung
Inhal Toxicol 2010 Dec;22 Suppl 2:117-25. PubMed:20828338
A critical review of naphthalene sources and exposures relevant to indoor and outdoor air. Int J Environ Res Public Health 2010 C. Jia, S. Batterman
Int J Environ Res Public Health 2010 07;7(7):2903-39. PubMed:20717549
Methodology for collecting, storing, and analyzing human milk for volatile organic compounds. J Environ Monit 2010 BC. Blount, DO. McElprang, DM. Chambers, MG. Waterhouse, KS. Squibb, JS. Lakind
J Environ Monit 2010 Jun;12(6):1265-73. PubMed:20358052
Cancer risk disparities between hispanic and non-hispanic white populations: the role of exposure to indoor air pollution. Environ. Health Perspect. 2009 DE. Hun, JA. Siegel, MT. Morandi, TH. Stock, RL. Corsi
Environ. Health Perspect. 2009 Dec;117(12):1925-31. PubMed:20049213
Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis. Environ. Res. 2009 J. Liu, W. Drane, X. Liu, T. Wu
Environ. Res. 2009 Feb;109(2):193-9. PubMed:19117555
Distributions of personal VOC exposures: a population-based analysis. Environ Int 2008 C. Jia, J. D'Souza, S. Batterman
Environ Int 2008 Oct;34(7):922-31. PubMed:18378311
Relationships between levels of volatile organic compounds in air and blood from the general population. J Expo Sci Environ Epidemiol 2008 YS. Lin, PP. Egeghy, SM. Rappaport
J Expo Sci Environ Epidemiol 2008 Jul;18(4):421-9. PubMed:18059425
Unmetabolized VOCs in urine as biomarkers of low level exposure in indoor environments. J Occup Health 2007 BL. Wang, T. Takigawa, A. Takeuchi, Y. Yamasaki, H. Kataoka, DH. Wang, K. Ogino
J Occup Health 2007 Mar;49(2):104-10. PubMed:17429167
A cancer risk assessment of inner-city teenagers living in New York City and Los Angeles. Environ. Health Perspect. 2006 SN. Sax, DH. Bennett, SN. Chillrud, J. Ross, PL. Kinney, JD. Spengler
Environ. Health Perspect. 2006 Oct;114(10):1558-66. PubMed:17035143
Using biologic markers in blood to assess exposure to multiple environmental chemicals for inner-city children 3-6 years of age. Environ. Health Perspect. 2006 K. Sexton, JL. Adgate, AL. Fredrickson, AD. Ryan, LL. Needham, DL. Ashley
Environ. Health Perspect. 2006 Mar;114(3):453-9. PubMed:16507471
Organic air pollutants inside and outside residences in Shimizu, Japan: levels, sources and risks. Sci. Total Environ. 2006 T. Ohura, T. Amagai, Y. Senga, M. Fusaya
Sci. Total Environ. 2006 Aug;366(2-3):485-99. PubMed:16298419
Snoring in primary school children and domestic environment: a Perth school based study. Respir. Res. 2004 G. Zhang, J. Spickett, K. Rumchev, AH. Lee, S. Stick
Respir. Res. 2004 Nov;5:19. PubMed:15527500
Outdoor, indoor, and personal exposure to VOCs in children. Environ. Health Perspect. 2004 JL. Adgate, TR. Church, AD. Ryan, G. Ramachandran, AL. Fredrickson, TH. Stock, MT. Morandi, K. Sexton
Environ. Health Perspect. 2004 Oct;112(14):1386-92. PubMed:15471730
A comparison of indoor air pollutants in Japan and Sweden: formaldehyde, nitrogen dioxide, and chlorinated volatile organic compounds. Environ. Res. 2004 K. Sakai, D. Norbäck, Y. Mi, E. Shibata, M. Kamijima, T. Yamada, Y. Takeuchi
Environ. Res. 2004 Jan;94(1):75-85. PubMed:14643289
Respiratory symptoms and peak expiratory flow in children with asthma in relation to volatile organic compounds in exhaled breath and ambient air. J Expo Anal Environ Epidemiol 2003 RJ. Delfino, H. Gong, WS. Linn, Y. Hu, ED. Pellizzari
J Expo Anal Environ Epidemiol 2003 Sep;13(5):348-63. PubMed:12973363
Blood concentrations of selected volatile organic compounds and neurobehavioral performance in a population-based sample. Arch Environ Occup Health T. Wu, AJ. Bhanegaonkar, JW. Flowers
Arch Environ Occup Health 2006 Jan-Feb;61(1):17-25. PubMed:17503617
Impact of biogas digesters on cookhouse volatile organic compound exposure for rural Kenyan farmwomen. J Expo Sci Environ Epidemiol C. Dohoo, J. Read Guernsey, MD. Gibson, J. VanLeeuwen
J Expo Sci Environ Epidemiol 2015 Mar-Apr;25(2):167-74. PubMed:23899962

Associated curated diseases 0

No curated diseases are identified in current reference collection.

Associated abnormalities 1

Concept Name External ID Weighted Score Hits References
Tangier Disease 547.33 1
  1. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int

Associated chemicals 16

Concept Name External ID Definition Weighted Score Hits References
4-xylene 1000.0 9
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
  2. Use of new generation poly(styrene-divinylbenzene) resins for gas-phase trapping-thermal desorption. Application to the retention of seven volatile organic compounds.
    P. López, R. Batlle, C. Nerín, J. Cacho, V. Ferreira (2007) J Chromatogr A
  3. Distributions of personal VOC exposures: a population-based analysis.
    C. Jia, J. D'Souza, S. Batterman (2008) Environ Int
  4. Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis.
    J. Liu, W. Drane, X. Liu, T. Wu (2009) Environ. Res.
  5. An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools.
    SC. Sofuoglu, G. Aslan, F. Inal, A. Sofuoglu (2011) Int J Hyg Environ Health
  6. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
  7. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int
Toluene CHEBI:17578 994.23 9
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
  2. Distributions of personal VOC exposures: a population-based analysis.
    C. Jia, J. D'Souza, S. Batterman (2008) Environ Int
  3. Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis.
    J. Liu, W. Drane, X. Liu, T. Wu (2009) Environ. Res.
  4. An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools.
    SC. Sofuoglu, G. Aslan, F. Inal, A. Sofuoglu (2011) Int J Hyg Environ Health
  5. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
  6. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int
Butadiene 941.36 5
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
  2. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int
chlorobenzene 1000.0 4
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
  2. On line biomonitors used as a tool for toxicity reduction evaluation of in situ groundwater remediation techniques.
    E. Küster, F. Dorusch, C. Vogt, H. Weiss, R. Altenburger (2004) Biosens Bioelectron
  3. An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools.
    SC. Sofuoglu, G. Aslan, F. Inal, A. Sofuoglu (2011) Int J Hyg Environ Health
Naphthalene CHEBI:16482 981.95 3
  1. An assessment of indoor air concentrations and health risks of volatile organic compounds in three primary schools.
    SC. Sofuoglu, G. Aslan, F. Inal, A. Sofuoglu (2011) Int J Hyg Environ Health
  2. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
3-xylene 1000.0 2
  1. Use of new generation poly(styrene-divinylbenzene) resins for gas-phase trapping-thermal desorption. Application to the retention of seven volatile organic compounds.
    P. López, R. Batlle, C. Nerín, J. Cacho, V. Ferreira (2007) J Chromatogr A
  2. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
2-chlorotoluene 1000.0 2
  1. On line biomonitors used as a tool for toxicity reduction evaluation of in situ groundwater remediation techniques.
    E. Küster, F. Dorusch, C. Vogt, H. Weiss, R. Altenburger (2004) Biosens Bioelectron
Acetaldehyde CHEBI:15343 1000.0 2
  1. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int
Hydrocarbons, Aromatic CHEBI:33658 952.52 2
  1. Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis.
    J. Liu, W. Drane, X. Liu, T. Wu (2009) Environ. Res.
tert-butylbenzene 1000.0 1
  1. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
styrene-butadiene rubber 923.0 1
  1. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int
trichlorobenzene 944.0 1
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
Cyclohexane 1000.0 1
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
Dichloropropane 930.5 1
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
Water Specimen 870.79 1
  1. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
tenax 847.0 1
  1. Use of new generation poly(styrene-divinylbenzene) resins for gas-phase trapping-thermal desorption. Application to the retention of seven volatile organic compounds.
    P. López, R. Batlle, C. Nerín, J. Cacho, V. Ferreira (2007) J Chromatogr A

Associated functions 3

Concept Name External ID Definition Weighted Score Hits References
Analyte 1000.0 2
  1. Spatial and temporal variability of priority volatile organic compounds in the Scheldt estuary.
    T. Huybrechts, J. Dewulf, H. Van Langenhove () Water Res.
  2. Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
    C. Rodriguez, K. Linge, P. Blair, F. Busetti, B. Devine, P. Van Buynder, P. Weinstein, A. Cook (2012) Water Res.
dose-response relationship 991.23 1
  1. On line biomonitors used as a tool for toxicity reduction evaluation of in situ groundwater remediation techniques.
    E. Küster, F. Dorusch, C. Vogt, H. Weiss, R. Altenburger (2004) Biosens Bioelectron
Inspiration function 686.0 1
  1. Risk assessment of population inhalation exposure to volatile organic compounds and carbonyls in urban China.
    Z. Du, J. Mo, Y. Zhang (2014) Environ Int

Associated genes 0

No associated genes are detected in current reference collection.

There are 22 associated references with 1,4-dichlorobenzene. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C6H4Cl2
Mass 146.998
Synonyms 1,4-DICHLOROBENZENE
p-Dichlorobenzene
106-46-7
paradichlorobenzene
Paracide
Paramoth
para-Dichlorobenzene
Dichlorobenzene
Paranuggets
Santochlor
Paradow
Evola
Persia-perazol
p-Dichlorobenzol
p-Chlorophenyl chloride
Globol
p-Dichlorbenzol
Para crystals
Benzene, 1,4-dichloro-
Dichlorocide
Paradi
Di-chloricide
Paradichlorbenzol
PARA
PDCB
p-Diclorobenzene
1,4-Dichloorbenzeen
p-Dichloorbenzeen
Paradichlorobenzol
1,4-Dichlor-benzol
1,4-Diclorobenzene
Benzene, p-dichloro-
dichloricide
Parazene
RCRA waste number U070
RCRA waste number U071
RCRA waste number U072
1,4-dichloro-benzene
Para-zene
4-Dichlorobenzene
NCI-C54955
p-DCB
Caswell No. 632
Kaydox
p-Dichlorbenzene
p-Dichlorbenzol [German]
p-Dichloorbenzeen [Dutch]
Paradichlorbenzol [German]
UNII-D149TYB5MK
p-Diclorobenzene [Italian]
PDB
NSC 36935
1,4-chlorobenzene
CCRIS 307
1,4-Dichloorbenzeen [Dutch]
1,4-Dichlor-benzol [German]
1,4-Diclorobenzene [Italian]
Dichlorobenzene, para
HSDB 523
EINECS 203-400-5
RCRA waste no. D027
RCRA waste no. U072
EPA Pesticide Chemical Code 061501
D149TYB5MK
AI3-0050
AI3-00050
CHEMBL190982
CHEBI:28618
OCJBOOLMMGQPQU-UHFFFAOYSA-N
NCGC00094540-01
1,3-Cyclohexadien-5-yne,1,4-dichloro-
DSSTox_CID_431
DSSTox_RID_75582
DSSTox_GSID_20431
73513-56-1
C6H4Cl2
1,4-dichlorbenzol
CAS-106-46-7
Dichlorobenzene, p-
1,4 dichlorobenzene
Dichlorobenzene, 1,4-
diclorobenzene
p-dichlorobenzen
Moth Nuggets
p-dichloro-benzene
Benzene,4-dichloro-
96384-17-7
Dichlorobenzene, solid
1, 4-Dichlorobenzene
Spectrum_001891
ACMC-1BDGR
SpecPlus_000512
1,3-Cyclohexadien-5-yne, 1,4-dichloro-
AC1Q3OEE
Benzene, 1,4-dichloro-, radical ion(1-)
Spectrum2_001869
Spectrum3_000846
Spectrum4_000686
Spectrum5_002008
p-Dichlorbenzol(GERMAN)
p-Dichloorbenzeen(DUTCH)
Para-Dichlorobenzene,(S)
WLN: GR DG
1,4-Dichlorobenzene paste
EC 203-400-5
p-Diclorobenzene(ITALIAN)
AC1L1IQ1
Dichlorobenzene, p-, solid
SCHEMBL5191
BSPBio_002431
KBioGR_001151
KBioSS_002421
SPECTRUM330055
KSC176S3J
BIDD:ER0278
DivK1c_006608
SPBio_001718
1, 4-Dichloorbenzeen(DUTCH)
1,4-Dichlor-benzol(GERMAN)
1,4-Diclorobenzene(ITALIAN)
DTXSID1020431
1,4-Dichlorobenzene, >=99%
CTK0H6934
KBio1_001552
KBio2_002415
KBio2_004983
KBio2_007551
KBio3_001931
KS-00000VTW
MolPort-001-770-272
LS-58
ZINC388507
NSC36935
Tox21_111293
Tox21_200399
Tox21_300018
1,4-Dichlorobenzene-UL-14C, neat
ANW-42346
BDBM50159263
c0593
CCG-39407
MFCD00000604
NSC-36935
STL445582
AKOS000120016
AS06944
MCULE-2384194593
NE10041
RL00286
RTR-032501
TRA0038301
UN 1592
1,4-Dichlorobenzene (ACD/Name 4.0)
1,4-Dichlorobenzene (p-dichlorobenzene)
NCGC00094540-02
NCGC00094540-03
NCGC00094540-04
NCGC00094540-05
NCGC00253934-01
NCGC00257953-01
55232-43-4
CJ-03279
S679
SC-79050
ZB011558
Benzene,1-chloro-4-(chloro-38cl)-(9ci)
KB-309476
TR-032501
D0687
FT-0606862
S0666
1,4-Dichlorobenzene 10 microg/mL in Isooctane
C07092
1,4-Dichlorobenzene 100 microg/mL in Methanol
1,4-Dichlorobenzene 1000 ng/microl in Methanol
1,4-Dichlorobenzene, SAJ first grade, >=99.0%
177753-EP2272510A1
I01-6761
J-503986
1,4-Dichlorobenzene, PESTANAL(R), analytical standard
F0001-0123
InChI=1/C6H4Cl2/c7-5-1-2-6(8)4-3-5/h1-4
UNII-F56X88UAJQ component OCJBOOLMMGQPQU-UHFFFAOYSA-N
Adipic acid, 1,3-butylene glycol copolymer, di(C14-C18) alkylcarboxylate
Hexanedioic acid, polymer with 1,3-butanediol, diesters with C14-18 fatty acids
1,4-DICHLOROBENZENE (P-DICHLOROBENZENE) (SEE ALSO: 1,2-DICHLOROBENZENE (95-50-1)& 1,3-DICHLOROBENZENE (541-73-1))
68890-93-7
PubChem CID 4685