DL-Lysine

Description

Description of DL-Lysine with associated disease summary

N(epsilon)-carboxymethyllysine(CML), the metabolic product of lysine, is an important biomarker of advanced glycation end products (AGEs). The increased concentrations of CML have been found to associate with diabetes mellitus, Alzheimer's disease, atherosclerosis and liver cirrhosis. The authors have developed a new analytical method to achieve simultaneous quantification of lysine and CML for investigate the ratio of CML to lysine in EBC (Exhaled Breath Condensate) as a specific indicator of AGE formation. The authors analyzed the ratio of CML to the precursor lysine in the EBC samples of dialysis and health subjects. They found a trend of higher CML/lysine is associated with dialysis, though it did not reach the statistical significance (p = 0.094) (Anal Bioanal Chem. (2007)). Description of disease(s) related to Lysine:

Disease summary

Healthy controls

The amount of CML was higher (Anal Bioanal Chem. (2007)).

Diabetic nephropathy

The amount of CML is low, and the amount of lysine is high (Anal Bioanal Chem. (2007)).

Summary of extracted biomedical information

Imgsrv

Associated references with human 6

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Reference title

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Journal Year Authors & PubMed Link
Potential roles of pentosidine in age-related and disease-related impairment of pulmonary functions in patients with asthma. J. Allergy Clin. Immunol. 2011 H. Kanazawa, Y. Tochino, S. Kyoh, Y. Ichimaru, K. Asai, K. Hirata
J. Allergy Clin. Immunol. 2011 Apr;127(4):899-904. PubMed:21215998
Inhibition of the interactions between eosinophil cationic protein and airway epithelial cells by traditional Chinese herbs. BMC Syst Biol 2010 HT. Chang, LJ. Tseng, TJ. Hung, BT. Kao, WY. Lin, TC. Fan, MD. Chang, TW. Pai
BMC Syst Biol 2010 Sep;4 Suppl 2:S8. PubMed:20840735
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation. Mol. Cell 2009 H. Neumann, SM. Hancock, R. Buning, A. Routh, L. Chapman, J. Somers, T. Owen-Hughes, J. van Noort, D. Rhodes, JW. Chin
Mol. Cell 2009 Oct;36(1):153-63. PubMed:19818718
Hereditary alpha-1-antitrypsin deficiency and its clinical consequences. Orphanet J Rare Dis 2008 L. Fregonese, J. Stolk
Orphanet J Rare Dis 2008 Jun;3:16. PubMed:18565211
Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2008 HC. Kim, M. Mofarrahi, SN. Hussain
Int J Chron Obstruct Pulmon Dis 2008 ;3(4):637-58. PubMed:19281080
A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J. 2003 TT. Hansel, SA. Kharitonov, LE. Donnelly, EM. Erin, MG. Currie, WM. Moore, PT. Manning, DP. Recker, PJ. Barnes
FASEB J. 2003 Jul;17(10):1298-300. PubMed:12738811

Associated curated diseases 0

No curated diseases are identified in current reference collection.

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 6 associated references with DL-Lysine. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 6 associated references with DL-Lysine. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 6 associated references with DL-Lysine. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 6 associated references with DL-Lysine. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C6H14N2O2
Mass 146.19
Synonyms DL-Lysine
2,6-diaminohexanoic acid
70-54-2
H-DL-Lys-OH
Lysine, DL-
2,6-bis(azanyl)hexanoic acid
CHEBI:25094
KDXKERNSBIXSRK-UHFFFAOYSA-N
AK-81251
ST50824025
EN300-34227
Q-201026
L-Lysine base
Lysine #
Lysine, hydrochloride (1:1)
(RS)-Lysine
(+-)-Lysine
laevo-lysine
CCRIS 8600
DL-Lysine base
PubChem CID 866