Kynurenine
Description
Description of kynurenine with associated disease summary
Kynurenine is a potential biomarker of asthma. To detect and
quantify acetate, LC-MS/MS method is applied. One study hypothesized that the
pulmonary tryptophan-catabolising enzyme indoleamine 2,3-dioxygenase (IDO) inhibited
by Th4 cytokines is impaired in allergic asthma patients according to the Th4
cytokine profiles in asthma patients (Thorax. (2013)). In
addition, this study attempted to find the relation between the rhinovirus
infection and IDO because allergic asthma is frequently caused by rhinovirus
infection (Thorax. (2013)).
The downstream product of IDO including kynurenine and quinolinic acid were
decreased in asthma patients. This result supports the first hypothesis that
the pulmonary IDO activity is impaired in patients. However, low-dose
rhinovirus infection did not change the IDO activities in both healthy controls
and asthma patients (Thorax.
(2013)).
Description of disease(s) related to kynurenine:
Asthma
The concentrations of EBC kynurenine decreased in asthma patients (Thorax. (2013)) compared with healthy control. This result supports the hypothesis that the pulmonary IDO activities are impaired in patients (Thorax. (2013)). However, the rhinovirus infection which is linked to the asthma cannot change the pulmonary IDO activities in patients.Summary of extracted biomedical information
Kynurenine is associated with abnormalities such as Oxygen toxicity and Convulsions. Kynurenine is associated with Amines and indole.
Associated references with human 3
Download references|
Reference title
with link to reference page |
Journal | Year | Authors & PubMed Link |
|---|---|---|---|
| (13)C-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder. | Sci Rep | 2015 |
T. Teraishi, H. Hori, D. Sasayama, J. Matsuo, S. Ogawa, M. Ota, K. Hattori, M. Kajiwara, T. Higuchi, H. Kunugi
Sci Rep 2015 Nov;5:15994. PubMed:26524975 |
| Oxidative modification of proteins in pediatric cystic fibrosis with bacterial infections. | Oxid Med Cell Longev | 2014 |
I. Sadowska-Bartosz, S. Galiniak, G. Bartosz, M. Rachel
Oxid Med Cell Longev 2014 ;2014:389629. PubMed:24803981 |
| Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway. | Free Radic. Biol. Med. | 1998 |
Y. Dang, C. Xia, OR. Brown
Free Radic. Biol. Med. 1998 Dec;25(9):1033-43. PubMed:9870556 |
Associated curated diseases 1
Download diseasesAssociated disease mapping
Mapping of all associated diseases to kynurenine is displayed in red.
|
Disease Name
with link to disease page |
Description of MeSH term
with link to MeSH Database |
Number of references |
|---|---|---|
| Asthma |
MeSH:
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and
intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of
airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
|
91 |
Associated abnormalities 2
| Concept Name | External ID | Weighted Score | Hits | References | |
| Oxygen toxicity | 1000.0 | 1 |
|
||
| Convulsions | 965.25 | 1 |
|
Associated chemicals 2
| Concept Name | External ID | Definition | Weighted Score | Hits | References | |
| Amines | CHEBI:32952 | 811.67 | 1 |
|
||
| indole | CHEBI:35581 | 895.0 | 1 |
|
Associated functions 0
No associated functions are detected in current reference collection.
There are 3 associated references with kynurenine. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 3 associated references with kynurenine. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
Chemical Information
| Formula | C10H12N2O3 |
| Mass | 208.217 |
| Synonyms | kynurenine 343-65-7 dl-Kynurenine 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 3-Anthraniloyl-DL-alanine 3-Anthraniloylalanine (+-)-Kynurenine 3-anthraniloyl-alanine Alanine, 3-anthraniloyl- Kynurenin Alanine, 3-anthraniloyl-, DL- CHEBI:28683 ST057185 alpha-2-Diamino-gamma-oxobenzenebutyric acid K-9000 K-9002 Benzenebutanoic acid, alpha,2-diamino-gamma-oxo- Quinurenine Benzenebutanoic acid, .alpha.,2-diamino-.gamma.-oxo- beta-Anthraniloyl-L-alanine |
| PubChem CID | 846 |