Pentanal

Description

Description of pentanal with associated disease summary

Pentanal is an alkyl aldehyde. The potential diagnostic value for lung cancer make pentanal and other aldehyde become desirable test analytes (J Chromatogr A. (2015)). To extract this compound and other aldehydes, magnetic solid-phase extraction combined with HPLC (MSPE-HPLC) and in-tube solid phase microextraction (IT-SPME) were developed. These two method can achieve both low detection limit and desirable linearity (J Chromatogr A. (2014), J Chromatogr A. (2015)). In these two studies, calibration curves of pentanal and other 5 aldehydes including butanal, hexanal heptanal, octanal and nonanal were evaluated and used to quantified the concentrations between healthy controls and lung cancer patients. In the first study, the concentration levels of pentanal and nonanal in lung cancer patients is higher than healthy control. However, in the second study, the level of concentration of pentanal in lung cancer patints do not significantly different to healthy controls (J Chromatogr A. (2015)). More additional study is necessary to be performed to take other conditions into consideration including diets habit, sex, and smoking (J Chromatogr A. (2014)). Description of disease(s) related to pentanal:

Disease summary

Lung Neoplasms

The concentration levels of pentanal in lung cancer patients are higher than the healthy control using MSPE-HPLC extraction method (J Chromatogr A. (2014)). However, the more recent studies using IT-SPME method do not support the previous statement. Instead, other five aldehydes including butanal, hexanal heptanal, octanal and nonanal shows the higher level of concentration in lung cancer patients. More additional study is necessary to be performed to find the specified aldehyde biomarker in lung cancer patients.

Summary of extracted biomedical information

Imgsrv

Associated references with human 1

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Reference title

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Journal Year Authors & PubMed Link
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to pentanal is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

with link to MeSH Database

Number of references
Non Small Cell Lung Cancer, Lung Neoplasms MeSH: Lung Neoplasms
Tumors or cancer of the LUNG.
Link to MeSH Database: D008175
4

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 1 associated references with pentanal. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 1 associated references with pentanal. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 1 associated references with pentanal. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 1 associated references with pentanal. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C5H8O
Mass 84.118
Synonyms
PubChem CID 59270504