15-epi-lipoxin A4

Description

Description of 15-epi-lipoxin A4 with associated disease summary

Lipoxins, including lipoxin A4, are a unique class of eicosanoids derived from 15-lipoxigenase oxidation of arachidonic acid to 15-HETE. Lipoxins promote resolution of cytokine-driven acute inflammation in the lung. Increased lipoxin A4 level in blood and respiratory samples had been noted in patients with asthma, cystic fibrosis, COPD and scleroderma lung disease. As for lipoxin A4 in EBC, it has been reported to be associated with asthma and its severity. Hasan et al. found in children hospitalized for status asthmaticus (n=20, mean age 11.9 +/- 2.9y/o) that, the level of lipoxin A4 in EBC was decreased when compared to healthy controls (n=16, age 12 +/- 3.3y/o) (Pediatr Crit Care Med. (2012)). Kazani et al. found EBC LXA4 level was 10-fold increased in adult asthma patients of all severity (mild asthma, n=10, age 33 +/- 12; moderate asthma, n=23, age 33 +/- 10; severe asthma n=36, age 42 +/- 11) than healthy controls (n=12, age 27 +/- 4). In asthma patients, EBC LXA4 level was positively associated with airflow obstruction measured as FEV1 percent predicted (r=0.28 and P=0.018). And the ratio of LXA4/LTB4 decreased with increased asthma severity. The mean LXA4/LTB4 ratio was 41% lower in the patients with severe asthma when compared with moderate ones (p=0.034) (J Allergy Clin Immunol. (2013)). In both studies, EIA was used to determine EBC LXA4 concentrations. GC/MS was used to validate the assays in the study by Hasan et al. (Pediatr Crit Care Med. (2012)). Description of disease(s) related to lipoxin A4 (LXA4):

Disease summary

Asthma

Kazani et al. found EBC LXA4 level was 10-fold increased in adult asthma patients of all severity (mild asthma, n=10, age 33 +/- 12; moderate asthma, n=23, age 33 +/- 10; severe asthma n=36, age 42 +/- 11) than healthy controls (n=12, age 27 +/- 4). In asthma patients, EBC LXA4 level was positively associated with airflow obstruction measured as FEV1 percent predicted (r=0.28 and P=0.018). And the ratio of LXA4/LTB4 decreased with increased asthma severity. The mean LXA4/LTB4 ratio was 41% lower in the patients with severe asthma when compared with moderate ones (p=0.034) (J Allergy Clin Immunol. (2013)).

Status Asthmaticus

Hasan et al. found in children hospitalized for status asthmaticus (n=20, mean age 11.9 +/- 2.9y/o) that, the level of lipoxin A4 in EBC was decreased when compared to healthy controls (n=16, age 12 +/- 3.3y/o) (Pediatr Crit Care Med. (2012)).

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 15-epi-lipoxin A4 is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91
Status Asthmaticus	MeSH: Status Asthmaticus A sudden intense and continuous aggravation of a state of asthma, marked by dyspnea to the point of exhaustion and collapse and not responding to the usual therapeutic efforts. Year introduced: 1991(1985) Link to MeSH Database: D013224	2

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 15-epi-lipoxin A4. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 15-epi-lipoxin A4. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 15-epi-lipoxin A4. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 15-epi-lipoxin A4. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₂₀H₃₂O₅
Mass	352.471
Synonyms	15-epi-lipoxin A4 15-epi-LXA(,4) 5(S),6(R),15(R)-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid HMDB12587 ZINC45789140 5(S),6(R),15(R)-trihydroxy-7E,9E,11Z,13E-eicosatetraenoate 5(S),6(R),15(R)-trihydroxy-7,9,13-trans-11-cis eicosatetraenoate 5(S),6(R),15(R)-trihydroxy-7,9,13-trans-11-cis eicosatetraenoic acid 5(S),6(R),15(R)-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid anion 5(S),6(R),15(R)-trihydroxy-7,9,13-trans-11-cis eicosatetraenoic acid anion
PubChem CID	52224362