Summary of extracted biomedical information
Butane-2,3-dione is associated with abnormalities such as Bronchiolitis Obliterans, Asthma, Airway Obstruction, Asthma attack NOS and Lung diseases. The involved biomedical functions are known as Respiratory physiology, Respiration, Occupational hazard, pulmonary function and Extravasation. Butane-2,3-dione is associated with Acetaldehyde, n-hexanal, isopentyl alcohol, 2-pentanone and Pentanedione.
Reference title
with link to reference page
|
Journal |
Year |
Authors & PubMed Link |
Inhalation dosimetry modeling provides insights into regional respiratory tract toxicity of inhaled diacetyl. |
Toxicology |
2017 |
JA. Cichocki, JB. Morris
Toxicology 2017 08;388:30-39.
PubMed:27851905
|
Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers. |
J Occup Environ Hyg |
2016 |
MG. Duling, RF. LeBouf, JM. Cox-Ganser, K. Kreiss, SB. Martin, RL. Bailey
J Occup Environ Hyg 2016 10;13(10):770-81.
PubMed:27105025
|
A review of the volatiles from the healthy human body. |
J Breath Res |
2014 |
B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001.
PubMed:24421258
|
Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility. |
Occup Environ Med |
2014 |
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss
Occup Environ Med 2014 Aug;71(8):549-54.
PubMed:24891557
|
Diacetyl exposures at four microwave popcorn plants. |
J Occup Environ Hyg |
2010 |
KL. White, K. Heikkila, R. Williams, L. Levin, JE. Lockey, C. Rice
J Occup Environ Hyg 2010 Apr;7(4):185-93.
PubMed:20094938
|
A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings. |
Occup Environ Med |
2009 |
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik
Occup Environ Med 2009 Feb;66(2):105-10.
PubMed:18805877
|
A case of flavor-induced lung disease. |
South. Med. J. |
2008 |
P. Modi, V. Yadava, R. Sreedhar, F. Khasawaneh, RA. Balk
South. Med. J. 2008 May;101(5):541-2.
PubMed:18414158
|
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. |
N. Engl. J. Med. |
2002 |
K. Kreiss, A. Gomaa, G. Kullman, K. Fedan, EJ. Simoes, PL. Enright
N. Engl. J. Med. 2002 Aug;347(5):330-8.
PubMed:12151470
|
No curated diseases are identified in current reference collection.
Concept Name |
External ID |
Weighted Score |
Hits |
References |
Bronchiolitis Obliterans |
|
1000.0 |
4 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Asthma |
ICD9-CM:493.9 |
1000.0 |
2 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Airway Obstruction |
|
1000.0 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Asthma attack NOS |
|
882.35 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Lung diseases |
|
930.5 |
1 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Occupational lung disease |
|
1000.0 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Chronic Obstructive Airway Disease |
|
1000.0 |
1 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Bronchitis, Chronic |
ICD9-CM:491 |
973.68 |
1 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Concept Name |
External ID |
Definition |
Weighted Score |
Hits |
References |
Acetaldehyde |
CHEBI:15343 |
|
988.8 |
3 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
n-hexanal |
|
|
888.89 |
3 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
isopentyl alcohol |
|
|
1000.0 |
3 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
2-pentanone |
|
|
1000.0 |
3 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
Pentanedione |
|
|
944.0 |
2 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
dinitrophenylhydrazine |
|
|
1000.0 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Coal |
|
|
1000.0 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
isovalerylaldehyde |
|
|
916.67 |
1 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
Concept Name |
External ID |
Definition |
Weighted Score |
Hits |
References |
Respiratory physiology |
|
|
744.39 |
6 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Respiration |
|
|
850.89 |
3 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Occupational hazard |
|
|
1000.0 |
2 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
pulmonary function |
|
|
945.0 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Extravasation |
|
|
790.69 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
Vital capacity |
|
|
873.07 |
1 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Obstruction |
|
|
1000.0 |
1 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Adverse effects |
|
|
1000.0 |
1 |
- Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
|
|
Evolution |
|
|
1000.0 |
1 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
Oxidation |
|
|
887.5 |
1 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
Sterility |
|
|
675.89 |
1 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
Bioluminescence |
|
|
893.17 |
1 |
- Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
|
|
volatile substances |
|
|
736.84 |
1 |
- A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
|
|
There are 8 associated references with Butane-2,3-dione. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
Formula |
C4H6O2 |
Mass |
86.09 |
Synonyms |
2,3-butanedione diacetyl biacetyl Butane-2,3-dione 431-03-8 dimethylglyoxal 2,3-diketobutane Dimethyl glyoxal Butanedione dimethyl diketone 2,3-Butadione 2,3-dioxobutane Glyoxal, dimethyl- 2,3-butandione Diacetyl (natural) Butan-2,3-dione CCRIS 827 FEMA No. 2370 HSDB 297 NSC 8750 2.3-butanedione UNII-K324J5K4HM UN2346 AI3-03313 EINECS 207-069-8 BRN 0605398 K324J5K4HM CHEBI:16583 QSJXEFYPDANLFS-UHFFFAOYSA-N Butanedione [UN2346] [Flammable liquid] 2,3-Butanedione-13C2 Biacetyl BDM 2,3 butandione Buta-2,3-dione Lopac-D-3634 Butanedione [UN2346] ACMC-1AE2K DSSTox_CID_1583 2,3-Butanedione, 97% AC1L19PK DSSTox_RID_76219 DSSTox_GSID_21583 Lopac0_000387 4-01-00-03644 (Beilstein Handbook Reference) Diacetyl, natural, >=95% KSC235Q7P WLN: 1VV1 (CH3CO)2 CHEMBL365809 SGCUT00113 DTXSID6021583 2,3-Butanedione (8CI,9CI) BDBM22725 CTK1D5877 KS-00000VRZ NSC8750 MolPort-001-768-865 HMS3261M15 NSC-8750 to_000005 ZINC1532732 Tox21_201218 Tox21_500387 ANW-41516 BBL027725 LMFA12000012 LS-116 MFCD00008756 2,3-Butanedione, analytical standard AKOS000118816 AN-1414 CCG-204481 LP00387 MCULE-5742661187 RP18441 RTR-016761 NCGC00015336-01 NCGC00015336-02 NCGC00015336-03 NCGC00015336-04 NCGC00015336-05 NCGC00015336-06 NCGC00090746-01 NCGC00090746-02 NCGC00090746-03 NCGC00258770-01 NCGC00261072-01 CAS-431-03-8 KB-16658 R557 DB-003226 TR-016761 B0682 Butanedione [UN2346] [Flammable liquid] EU-0100387 FT-0609502 FT-0663924 C00741 D 3634 57419-EP2275409A1 57419-EP2275422A1 57419-EP2289483A1 57419-EP2298755A1 57419-EP2308878A2 157009-EP2283898A1 A826155 SR-01000075811 I14-1154 InChI=1/C4H6O2/c1-3(5)4(2)6/h1-2H SR-01000075811-1 DEE64962-0BD5-454C-8BDA-FDBD33C47181 F0001-1188 151677-70-2 BUO
|
PubChem CID |
650 |