Butane-2,3-dione

Summary of extracted biomedical information

Butane-2,3-dione is associated with abnormalities such as Bronchiolitis Obliterans, Asthma, Airway Obstruction, Asthma attack NOS and Lung diseases. The involved biomedical functions are known as Respiratory physiology, Respiration, Occupational hazard, pulmonary function and Extravasation. Butane-2,3-dione is associated with Acetaldehyde, n-hexanal, isopentyl alcohol, 2-pentanone and Pentanedione.
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Associated references with human 8

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Journal Year Authors & PubMed Link
Inhalation dosimetry modeling provides insights into regional respiratory tract toxicity of inhaled diacetyl. Toxicology 2017 JA. Cichocki, JB. Morris
Toxicology 2017 08;388:30-39. PubMed:27851905
Environmental characterization of a coffee processing workplace with obliterative bronchiolitis in former workers. J Occup Environ Hyg 2016 MG. Duling, RF. LeBouf, JM. Cox-Ganser, K. Kreiss, SB. Martin, RL. Bailey
J Occup Environ Hyg 2016 10;13(10):770-81. PubMed:27105025
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility. Occup Environ Med 2014 KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss
Occup Environ Med 2014 Aug;71(8):549-54. PubMed:24891557
Diacetyl exposures at four microwave popcorn plants. J Occup Environ Hyg 2010 KL. White, K. Heikkila, R. Williams, L. Levin, JE. Lockey, C. Rice
J Occup Environ Hyg 2010 Apr;7(4):185-93. PubMed:20094938
A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings. Occup Environ Med 2009 FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik
Occup Environ Med 2009 Feb;66(2):105-10. PubMed:18805877
A case of flavor-induced lung disease. South. Med. J. 2008 P. Modi, V. Yadava, R. Sreedhar, F. Khasawaneh, RA. Balk
South. Med. J. 2008 May;101(5):541-2. PubMed:18414158
Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N. Engl. J. Med. 2002 K. Kreiss, A. Gomaa, G. Kullman, K. Fedan, EJ. Simoes, PL. Enright
N. Engl. J. Med. 2002 Aug;347(5):330-8. PubMed:12151470

Associated curated diseases 0

No curated diseases are identified in current reference collection.

Associated abnormalities 8

Concept Name External ID Weighted Score Hits References
Bronchiolitis Obliterans 1000.0 4
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
  2. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Asthma ICD9-CM:493.9 1000.0 2
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Airway Obstruction 1000.0 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Asthma attack NOS 882.35 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Lung diseases 930.5 1
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Occupational lung disease 1000.0 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Chronic Obstructive Airway Disease 1000.0 1
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Bronchitis, Chronic ICD9-CM:491 973.68 1
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med

Associated chemicals 8

Concept Name External ID Definition Weighted Score Hits References
Acetaldehyde CHEBI:15343 988.8 3
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
n-hexanal 888.89 3
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
isopentyl alcohol 1000.0 3
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
2-pentanone 1000.0 3
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
Pentanedione 944.0 2
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
dinitrophenylhydrazine 1000.0 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Coal 1000.0 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
isovalerylaldehyde 916.67 1
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.

Associated functions 13

Concept Name External ID Definition Weighted Score Hits References
Respiratory physiology 744.39 6
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
  2. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Respiration 850.89 3
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
  2. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Occupational hazard 1000.0 2
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
pulmonary function 945.0 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Extravasation 790.69 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med
Vital capacity 873.07 1
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Obstruction 1000.0 1
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Adverse effects 1000.0 1
  1. Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility.
    KJ. Cummings, RJ. Boylstein, ML. Stanton, CA. Piacitelli, NT. Edwards, RF. LeBouf, K. Kreiss (2014) Occup Environ Med
Evolution 1000.0 1
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
Oxidation 887.5 1
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
Sterility 675.89 1
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
Bioluminescence 893.17 1
  1. Volatile organic compounds and Photobacterium phosphoreum associated with spoilage of modified-atmosphere-packaged raw pork.
    TT. Nieminen, P. Dalgaard, J. Björkroth (2016) Int. J. Food Microbiol.
volatile substances 736.84 1
  1. A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings.
    FG. van Rooy, LA. Smit, R. Houba, VA. Zaat, JM. Rooyackers, DJ. Heederik (2009) Occup Environ Med

Associated genes 0

No associated genes are detected in current reference collection.

There are 8 associated references with Butane-2,3-dione. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C4H6O2
Mass 86.09
Synonyms 2,3-butanedione
diacetyl
biacetyl
Butane-2,3-dione
431-03-8
dimethylglyoxal
2,3-diketobutane
Dimethyl glyoxal
Butanedione
dimethyl diketone
2,3-Butadione
2,3-dioxobutane
Glyoxal, dimethyl-
2,3-butandione
Diacetyl (natural)
Butan-2,3-dione
CCRIS 827
FEMA No. 2370
HSDB 297
NSC 8750
2.3-butanedione
UNII-K324J5K4HM
UN2346
AI3-03313
EINECS 207-069-8
BRN 0605398
K324J5K4HM
CHEBI:16583
QSJXEFYPDANLFS-UHFFFAOYSA-N
Butanedione [UN2346] [Flammable liquid]
2,3-Butanedione-13C2
Biacetyl
BDM
2,3 butandione
Buta-2,3-dione
Lopac-D-3634
Butanedione [UN2346]
ACMC-1AE2K
DSSTox_CID_1583
2,3-Butanedione, 97%
AC1L19PK
DSSTox_RID_76219
DSSTox_GSID_21583
Lopac0_000387
4-01-00-03644 (Beilstein Handbook Reference)
Diacetyl, natural, >=95%
KSC235Q7P
WLN: 1VV1
(CH3CO)2
CHEMBL365809
SGCUT00113
DTXSID6021583
2,3-Butanedione (8CI,9CI)
BDBM22725
CTK1D5877
KS-00000VRZ
NSC8750
MolPort-001-768-865
HMS3261M15
NSC-8750
to_000005
ZINC1532732
Tox21_201218
Tox21_500387
ANW-41516
BBL027725
LMFA12000012
LS-116
MFCD00008756
2,3-Butanedione, analytical standard
AKOS000118816
AN-1414
CCG-204481
LP00387
MCULE-5742661187
RP18441
RTR-016761
NCGC00015336-01
NCGC00015336-02
NCGC00015336-03
NCGC00015336-04
NCGC00015336-05
NCGC00015336-06
NCGC00090746-01
NCGC00090746-02
NCGC00090746-03
NCGC00258770-01
NCGC00261072-01
CAS-431-03-8
KB-16658
R557
DB-003226
TR-016761
B0682
Butanedione [UN2346] [Flammable liquid]
EU-0100387
FT-0609502
FT-0663924
C00741
D 3634
57419-EP2275409A1
57419-EP2275422A1
57419-EP2289483A1
57419-EP2298755A1
57419-EP2308878A2
157009-EP2283898A1
A826155
SR-01000075811
I14-1154
InChI=1/C4H6O2/c1-3(5)4(2)6/h1-2H
SR-01000075811-1
DEE64962-0BD5-454C-8BDA-FDBD33C47181
F0001-1188
151677-70-2
BUO
PubChem CID 650