12,13-DiHOME(9)

Description

Description of 12,13-DiHOME(9) with associated disease summary

isoleukotoxindiol Linoleic acid metabolites such as monoepoxide, also known as isoleukotoxin, and its diol may be important lipid mediators regulating inflammation. The biosynthesis and toxicity of isoleukotoxin is presumed to be comparable to that of leukotoxin. The toxicity may be due to the isoleukotoxin diol, which has been shown to disrupt mitochondrial function and cause cytotoxicity. Due to their roles in inflammation and inflammatory lung conditions, a high performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method was developed to analyze the exhaled breath condensate (EBC) of 10 control non-asthmatics and 1 asthmatic individual for these metabolies. The method was validated, the accuracy was within 81-119% ( IEEE Sens J. (2010) ). Description of disease(s) related to Isoleukotoxin diol:

Asthma

The level of isoleukotoxin diol (12,13-DiHOME) is increased in the presence of asthma symptoms (IEEE Sens J. (2010)).

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to 12,13-DiHOME(9) is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 12,13-DiHOME(9). Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 12,13-DiHOME(9). Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 12,13-DiHOME(9). Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 12,13-DiHOME(9). Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₁₈H₃₄O₄
Mass	314.466
Synonyms	12,13-DiHOME(9) 12,13-dihydroxy-9-octadecenoic acid Isoleukotoxindiol AC1NR17G SCHEMBL1567607 LMFA02000164 (E)-12,13-dihydroxyoctadec-9-enoic acid
PubChem CID	5282961