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Does consumption of ethanol distort measurements of exhaled nitric oxide?
AW. Jones, M. Fransson, E. Maldonado-Holmertz
Respir Med 2005 Feb;99(2):196-9.
PubMed: 15715186
Abstract
Measuring FE(NO) is a novel and non-invasive way to monitor airway inflammation (e.g. asthma). This clinical study was designed to investigate whether drinking ethanol might distort FE(NO) measurements. Twenty healthy subjects drank 0.40 g ethanol/kg body weight in 15 min. Measurement of FE(NO) started approximately 30 min before drinking and at various times afterwards for 4 h post-dosing. Ethanol concentrations were determined in venous blood by gas chromatography and in end-exhaled breath by infra-red spectrometry. The within subject standard deviation for determination of FE(NO) was 1.3 ppb, corresponding to a CV of 7.7%. The mean change in FE(NO) from pre-drinking levels during the 4h testing was statistically significant (P<0.001) according to repeated measures ANOVA. In absolute units the mean change was small, -2.01 and -1.94 ppb at 3 and 4h post-dosing, respectively (P<0.013, P<0.005). FE(NO) measurements were reproducible even in subjects with moderate concentrations of ethanol in blood and breath. The small decrease in FE(NO) observed at 3 and 4 h post-drinking was less than the intra-subject variations in FE(NO) measurements. The breath-alcohol concentrations in this study exceed all other endogenous volatiles, thus making it unlikely that other substances in human breath will bias the FE(NO) measurements.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Nitric oxide | 276 |