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Urates in exhaled breath condensate as a biomarker of control in childhood asthma.
M. Navratil, D. Plavec, D. Erceg, S. Bulat Lokas, J. Živković, M. Turkalj
J Asthma 2015 Jun;52(5):437-46.
PubMed: 25387148
Abstract
The aim of this study was to (1) investigate the possibility to use urates in exhaled breath condensate (EBC) as a biomarker of airway inflammation and control in childhood asthma and (2) explore their association with other biomarkers of airway inflammation and clinical indices of asthma control (Asthma Control Test [ACT], quality of life [PAQLQ], lung function, prn beta-agonist use, time from last exacerbation [TLE]. This cross-sectional study comprised 103 consecutive patients (age 6-18 years) divided in groups of uncontrolled ([NC], n = 53) and controlled asthma ([C], n = 50). Measured lung function and biomarkers included: spirometry, eosinophilic cationic protein (ECP), high-sensitivity C-reactive protein (hs-CRP), exhaled NO (FENO), pH and urates in EBC and exhaled breath temperature (EBT). Statistically significant differences were found between groups for EBC urates, EBC pH and EBT (NC versus C: EBC urates, median [IQR], µmol/L; 10 [6] versus 45 [29], p
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Nitric oxide | 276 |