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MIN 14C UBT: a combination of gastric basal transit and 14C-urea breath test for the detection of Helicobacter pylori infection in human beings.
M. Zubillaga, P. Oliveri, ML. Calcagno, C. Goldman, R. Caro, A. Mitta, O. Degrossi, J. Boccio
Nucl. Med. Biol. 1997 Aug;24(6):565-9.
PubMed: 9316086
Abstract
The purpose of this work is to demonstrate that the 14C-urea breath test (UBT) performed at different times combined with the study of the gastric basal transit, which evaluates the intragastric displacement of a labeled solution under fasting conditions, has the advantage of being representative of the whole stomach surface and constitutes a non-aggressive test for the detection of H. pylori. This test, which has been called MIN 14C UBT, is a modification of the conventional 14C UBT in which low volumes of a solution of 14C-urea together with 99mTc-sulfur colloid are administered. The 99mTc-sulfur colloid is not absorbed in the gastrointestinal tract and has the great advantage of allowing the "visualization" of the transit of the 14C-urea within the gastrointestinal tract. This modification allows the simultaneous determination of the production of the 14CO2 and the place where this process occurs. The results show that there is a good correlation between the images obtained and the breath samples collected. We found that this test has a sensitivity of 98% and a specificity of 96% for H. pylori detection.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Urea | 1130 |