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Novel therapies for Helicobacter pylori infection.
AR. Opekun, HM. El-Zaimaity, MS. Osato, MA. Gilger, HM. Malaty, M. Terry, DR. Headon, DY. Graham
Aliment. Pharmacol. Ther. 1999 Jan;13(1):35-42.
PubMed: 9892877
Abstract
Increasing antibiotic resistance has begun to impair our ability to cure Helicobacter pylori infection. To evaluate orally administered novel therapies for the treatment of H. pylori infection. Healthy H. pylori infected volunteers received: (a) hyperimmune bovine colostral immune globulins, (b) an oligosaccharide containing an H. pylori adhesion target, Neu5Aca2-3Galb1-4Glc-(3'-sialyllactose), or (c) recombinant human lactoferrin. Outcome was assessed by urea breath test or histological assessment of the number of H. pylori present. None of the novel therapies appeared effective and no adverse events occurred. Although in vitro data appeared promising, in vivo results were disappointing. Higher doses, longer duration of therapy, adjunctive acid suppression, or a combination could possibly yield better results.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Urea | 1130 |