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A comparison of two rapid whole-blood tests and laboratory serology, in the diagnosis of Helicobacter pylori infection.
AB. Hawthorne, S. Morgan, D. Westmoreland, R. Stenson, GA. Thomas, RG. Newcombe
Eur J Gastroenterol Hepatol 1999 Aug;11(8):863-5.
PubMed: 10514118
Abstract
To compare two rapid whole-blood serology tests for Helicobacter pylori and a laboratory serology assay against a gold standard. Prospective comparison of tests in 81 patients. A hospital rapid access endoscopy clinic. Dyspeptic patients requiring assessment of H. pylori status. Measurement of H. pylori antibody status by Quickvue One-step, Helisal, and Premier H. pylori test; 13C urea breath test for H. pylori, and gastric biopsies for histology, culture and rapid urease test. Sensitivity and specificity of Quickvue One-step, Helisal and Premier tests, compared to a gold standard based on 13C urea breath test, biopsy culture, histology and urease test. The Quickvue assay has significantly greater sensitivity (81%) than Helisal (67%), but without appreciable loss of specificity (86% and 93%, respectively). The Premier laboratory assay is significantly more sensitive than both of the rapid blood tests (96%), with comparable specificity to the Quickvue assay. The rapid serology tests used in this study are quick and convenient to use, but do not approach the sensitivity of a laboratory assay in detecting H. pylori status in this group of dyspeptic patients attending an endoscopy clinic.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Urea | 1130 |