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Placental acquisition of maternal specific IgG and Helicobacter pylori colonization in infancy.
JE. Bunn, JE. Thomas, M. Harding, WA. Coward, LT. Weaver
Helicobacter 2003 ;8(5):568-72.
PubMed: 14536004
Abstract
Colonization with Helicobacter pylori generally occurs in infancy, and the microorganism is often acquired from close family members. Rate of infant colonization may be affected by maternal immune status. To investigate the potential protective effect of anti-H. pylori immunoglobulin G (IgG) acquired via the placenta, 65 mothers and their infants were studied from the infant's birth for 1 year. Circulating IgG antibodies were measured by enzyme-linked immunosorbent assay (ELISA) in cord blood and every 8 weeks. Immunoblotting was performed on sera from infants with significant increases in IgG levels. Rate of infant H. pylori colonization was measured by 13C urea breath tests every 4 weeks from the age of 12 weeks. Maternal and infant cord blood specific IgG levels were correlated (R2 =.747, p
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Urea | 1130 |