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Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project.
RF. Harvey, JA. Lane, LJ. Murray, IM. Harvey, JL. Donovan, P. Nair, .
BMJ 2004 Jun;328(7453):1417.
PubMed: 15126313
Abstract
To investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux. Cross sectional study, followed by a randomised placebo controlled trial. Seven general practices in Bristol, England. 10,537 people, aged 20-59 years, with and without H pylori infection (determined by the (13)C-urea breath test). Prevalence of heartburn and gastro-oesophageal acid reflux at baseline and two years after treatment to eradicate H pylori infection. At baseline, H pylori infection was associated with increased prevalence of heartburn (odds ratio 1.14, 95% confidence interval 1.05 to 1.23) but not reflux (1.05, 0.97 to 1.14). In participants with H pylori infection, active treatment had no effect on the overall prevalence of heartburn (0.99, 0.88 to 1.12) or reflux (1.04, 0.91 to 1.19) and did not improve pre-existing symptoms of heartburn or reflux. H pylori infection is associated with a slightly increased prevalence of heartburn but not reflux. Treatment to eradicate H pylori has no net benefit in patients with heartburn or gastro-oesophageal reflux.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Urea | 1130 |