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Elimination characteristics of disulfiram over time in five alcoholic volunteers: a preliminary study.
JC. Jensen, MD. Faiman, A. Hurwitz
Am J Psychiatry 1982 Dec;139(12):1596-8.
PubMed: 6293320
Abstract
The authors studied the elimination of disulfiram and its metabolites for 24 hours after disulfiram administration in five healthy male alcoholic volunteers. Using high-performance liquid chromatography, they found that a single 500-mg dose resulted in a gradual increase in plasma disulfiram and its metabolites, with peak levels generally occurring 8 hours after dosing. There was considerable interpatient variability (e.g., in one volunteer no disulfiram was detected during the entire 24-hour sampling period). The authors also found that breath carbon disulfide was 9.1% of the dose of disulfiram administered, which is less than that expected theoretically.
Associated compounds:
Compound Name
with link to compound page |
Structure | Number of references |
---|---|---|
Methanedithione | 39 |