Methanol

Description

Description of methanol with associated disease summary

Methanol is an important compound in carbon metabolism. To detect and quantify methanol, NMR method is applied. In one study about smoking-related diseases including chronic obstructive pulmonary disease (COPD) and pulmonary Langerhans cell histiocytosis (PLCH), the concentrations of ethanol, methanol and 2-propanol in COPD and PLCH patients are higher than healthy smokers (J Proteome Res. (2013)). However, the ethanol and methanol increase in both COPD and PLCH patients cannot be linked to the reduction of acetone by liver alcohol dehydrogenase due to no acetone variation is detected (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases. The methanol concentration difference also observed between stable cystic fibrosis patients and unstable cystic fibrosis patients using NMF detection method (Thorax. (2012)). Methanol concentration in unstable CF patients is also higher than the stable CF patients who had no change in cough or shortness of breath in the previous 4 weeks (Thorax. (2012)). Description of disease(s) related to methanol:

Chronic obstructive pulmonary disease (COPD)

The concentration of EBC methanol is increased in COPD patients (J Proteome Res. (2013)) . However, the methanol and ethanol increase in both COPD and PLCH patients cannot be linked to the reduction of acetone by liver alcohol dehydrogenase or other pathways (J Proteome Res. (2013)). More studies has to be performed to explain the relation between alcohols and smoking-related diseases.

Pulmonary Langerhans cell histiocytosis (PLCH)

Cystic fibrosis

The concentration of EBC ethanol is increased in unstable CF patients compared with stable CF patients who had no change in cough or shortness of breath in the previous 4 weeks (Thorax. (2012)).

Summary of extracted biomedical information

Associated references with human 2

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
Separating smoking-related diseases using NMR-based metabolomics of exhaled breath condensate.	J. Proteome Res.	2013	G. de Laurentiis, D. Paris, D. Melck, P. Montuschi, M. Maniscalco, A. Bianco, M. Sofia, A. Motta J. Proteome Res. 2013 Mar;12(3):1502-11. PubMed:23360153
NMR spectroscopy metabolomic profiling of exhaled breath condensate in patients with stable and unstable cystic fibrosis.	Thorax.	2012	P. Montuschi, D. Paris, D. Melck, V. Lucidi, G. Ciabattoni, V. Raia, C. Calabrese, A. Bush, PJ. Barnes, A. Motta Thorax. 2012 Mar;67(3):222-8. doi: 10.1136/thoraxjnl-2011-200072. Epub 2011 Nov 21. PubMed:22106016

Associated curated diseases 3

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Associated disease mapping

Mapping of all associated diseases to methanol is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Cystic Fibrosis	MeSH: Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967 Link to MeSH Database: D003550	20
Pulmonary Langerhans Cell Histiocytosis	MeSH: Histiocytosis, Langerhans-Cell A group of disorders resulting from the abnormal proliferation of and tissue infiltration by LANGERHANS CELLS which can be detected by their characteristic Birbeck granules (X bodies), or by monoclonal antibody staining for their surface CD1 ANTIGENS. Langerhans-cell granulomatosis can involve a single organ, or can be a systemic disorder. Year introduced: 1990(1975) Link to MeSH Database: D006646	1
Chronic Obstructive Pulmonary Disease (Copd)	MeSH: Pulmonary Disease, Chronic Obstructive A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002 Link to MeSH Database: D029424	31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 2 associated references with methanol. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 2 associated references with methanol. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 2 associated references with methanol. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 2 associated references with methanol. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	CHO
Mass	29.018
Synonyms
PubChem CID	101954077