Lysophosphatidic acid

Description

Description of lysophosphatidic acid with associated disease summary

Lysophosphatidic acid (LPA) is a biologically active lysophospholipid which is an essential to the development and progression of fibrosis. Several LPA species can be detected using LC-MS/MS method. The concentration of EBC Docosatetraenoyl (22:4) LPA is higher in idiopathic pulmonary fibrosis (IPF) subjects when compared to controls. More research is necessary to determine the significance of increase of 22:4 LPA in IPF EBC (BMC Pulm Med. (2014)). Description of disease(s) related to Lysophosphatidic acid (LPA):

Disease summary

Idiopathic Pulmonary Fibrosis (IPF)

The concentration of EBC Docosatetraenoyl (22:4) LPA is higher in idiopathic pulmonary fibrosis (IPF) subjects when compared to controls. More research is necessary to determine the significance of increase of 22:4 LPA in IPF EBC (BMC Pulm Med. (2014)).

Summary of extracted biomedical information

Associated references with human 0

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Reference title

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Journal Year Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to lysophosphatidic acid is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Idiopathic Pulmonary Fibrosis MeSH: Idiopathic Pulmonary Fibrosis
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. Year introduced: 2009
Link to MeSH Database: D054990 		3

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with lysophosphatidic acid. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with lysophosphatidic acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with lysophosphatidic acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with lysophosphatidic acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C21H41NaO7P
Mass 459.516
Synonyms LPA SODIUM
CTK8G0695
LP024105
PubChem CID 57369610