Description of thromboxane B2 with associated disease summary
Thromboxane B2Thromboxane A2 (TxA2) is implicated in inflammation in asthmatic airway. TxA2 is converted to chemically stable Thromboxane B2 (TxB2) rapidly, so TxB2 is measured instead of TxA2 in asthmatic subjects. TxB2 was usually measured by enzyme immunoassay (EIA). However, it was reported that TxB2 was undetectable in EIA. Authors have found radioimmunoassay (RIA) used in their lab may be useful in detecting TxB2 (Inflamm. Res, (2005)). Description of disease(s) related to Thromboxane B2:
AsthmaThromboxane B2 which is converted from Thromboxane A2 is higher measured concentrations in asthma subjects than in healthy subjects.
Summary of extracted biomedical informationThromboxane b2 is associated with abnormalities such as Asthma. The involved biomedical functions are known as Thromboxane Production, attenuation and Synthesis.
Associated references with human 4Download references
with link to reference page
|Journal||Year||Authors & PubMed Link|
|Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma.||J. Allergy Clin. Immunol.||2008||
D. Menzies, A. Nair, KT. Meldrum, P. Hopkinson, BJ. Lipworth
J. Allergy Clin. Immunol. 2008 May;121(5):1184-1189.e4. PubMed:18313127
|Role of nitric oxide in hemostatic system activation in vivo in humans.||Arterioscler. Thromb. Vasc. Biol.||1995||
K. Krejcy, L. Schmetterer, J. Kastner, M. Nieszpaur-Los, B. Monitzer, W. Schütz, HG. Eichler, PA. Kyrle
Arterioscler. Thromb. Vasc. Biol. 1995 Nov;15(11):2063-7. PubMed:7583590
|Limited maximal airway narrowing in nonasthmatic subjects. Role of neural control and prostaglandin release.||Am. Rev. Respir. Dis.||1985||
PJ. Sterk, EE. Daniel, N. Zamel, FE. Hargreave
Am. Rev. Respir. Dis. 1985 Oct;132(4):865-70. PubMed:2864892
|Contact urticaria and airway obstruction from carbonless copy paper.||JAMA||
JG. Marks, JJ. Trautlein, CW. Zwillich, LM. Demers
JAMA 1984 Aug 24-31;252(8):1038-40. PubMed:6235381
Associated curated diseases 1Download diseases
Associated disease mapping
Mapping of all associated diseases to thromboxane B2 is displayed in red.
with link to disease page
Description of MeSH term
with link to MeSH Database
|Number of references|
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).Link to MeSH Database: D001249
Associated abnormalities 1
|Concept Name||External ID||Weighted Score||Hits||References|
Associated chemicals 0
No associated chemicals are detected in current reference collection.
There are 4 associated references with thromboxane B2. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.
Associated functions 0
No associated functions are detected in current reference collection.
There are 4 associated references with thromboxane B2. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.
Associated genes 0
No associated genes are detected in current reference collection.
There are 4 associated references with thromboxane B2. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.
NCBI Entrez Crosslinks
PG Thromboxane B2
Thromboxa-5,13-dien-1-oic acid, 9,11,15-trihydroxy-, (5Z,9alpha,13E,15S)-