11-Dehydro-thromboxane B2

Description

Description of 11-Dehydro-thromboxane B2 with associated disease summary

11-dehydrothromboxane B2 (11-dehydro-TXB2) is a downstream product of arachidonic acid and prostaglandins G2 (PGG2) in eicosanoid biosynthetic pathways (Pediatr Pulmonol. (2013)). It can be detected using LC-MS/MS method. Unlike other eicosanoids which increase in asthmatic patients, the concentrations of EBC 11-dehydro-TXB2 in asthmatic patients are significantly lower than the healthy control (Pediatr Pulmonol. (2013)). Description of disease(s) related to 11-dehydrothromboxane B2 (11-dehydro-TXB2):

Disease summary

Asthma

The concentrations of EBC 11-dehydro-TXB2 in asthmatic patients are significantly lower than the healthy control (Pediatr Pulmonol. (2013)).

Summary of extracted biomedical information

Associated references with human 2

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Reference title

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Journal Year Authors & PubMed Link
Cardiovascular biomarkers in groups of established smokers after a decade of smoking. Basic Clin. Pharmacol. Toxicol. 2009 G. Calapai, AP. Caputi, C. Mannucci, GA. Russo, E. Gregg, R. Puntoni, F. Lowe, M. McEwan, A. Bassi, S. Morandi, A. Nunziata
Basic Clin. Pharmacol. Toxicol. 2009 Apr;104(4):322-8. PubMed:19175368
Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation. Arterioscler. Thromb. Vasc. Biol. 2005 G. Davì, M. Neri, A. Falco, D. Festi, T. Taraborelli, G. Ciabattoni, S. Basili, F. Cuccurullo, C. Patrono
Arterioscler. Thromb. Vasc. Biol. 2005 Jan;25(1):246-51. PubMed:15472127

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to 11-Dehydro-thromboxane B2 is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 2 associated references with 11-Dehydro-thromboxane B2. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 2 associated references with 11-Dehydro-thromboxane B2. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 2 associated references with 11-Dehydro-thromboxane B2. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 2 associated references with 11-Dehydro-thromboxane B2. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C20H32O6
Mass 368.47
Synonyms 11-Dehydro-thromboxane B2
11-Dehydro-txb2
11-Keto-thromboxane B2
11-dehydrothromboxane B2
CHEBI:28667
67910-12-7
9S,15S-dihydroxy-11-oxo-thromboxa-5Z,13E-dien-1-oic acid
(Z)-7-[(2R,3S,4S)-4-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-6-oxooxan-3-yl]hept-5-enoic acid
11-dehydro Thromboxane B2
AC1NQXQM
SCHEMBL501141
BML2-B08
GTPL4484
CHEMBL1405272
LMFA03030004
ZINC13815372
NCGC00161307-01
C05964
(5Z,13E,15S)-9alpha,15-dihydroxy-11-oxothromboxa-5,13-dien-1-oic acid
(5Z,9|A,13E,15S)-9,15-Dihydroxy-11-oxo-thromboxa-5,13-dien-1-oic Acid
PubChem CID 5280891