Prostaglandin E2

Description

Description of Prostaglandin E2 with associated disease summary

Prostaglandin E2 (PGE2) is a compound with potent anti-inflammatory activity and it can relax airway smooth muscles ( Arch Med Sci. (2012)). It can be detected using enzyme immunoassay (EIA) method. If PGE2-braking mechanism is failed or inhibited by nonsteroidal anti-inflammatory drugs (NSAID), the cysteinyl-leukotrienes (cys-LTs) will increase. The EBC PGE2 in chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) patients increased compared with healthy control (Arch Med Sci. (2012), Free Radic Biol Med. (2008)). Description of disease(s) related to Prostaglandin E2 (PGE2):

Disease summary

Chronic obstructive pulmonary disease (COPD)

The EBC PGE2 concentrations in COPD patients increased compared with healthy control (Arch Med Sci. (2012)).

Cystic fibrosis (CF)

The EBC PGE2 concentrations in CF patients increased compared with healthy control (Free Radic Biol Med. (2008)).

Summary of extracted biomedical information

Imgsrv

Associated references with human 1

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Reference title

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Journal Year Authors & PubMed Link
Validation of 8-isoprostane and prostaglandin E(2) measurements in exhaled breath condensate. Inflamm. Res. 2003 P. Montuschi, E. Ragazzoni, S. Valente, G. Corbo, C. Mondino, G. Ciappi, G. Ciabattoni
Inflamm. Res. 2003 Dec;52(12):502-7. PubMed:14991078

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Prostaglandin E2 is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Cystic Fibrosis MeSH: Cystic Fibrosis
An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967
Link to MeSH Database: D003550
20
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 1 associated references with Prostaglandin E2. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 1 associated references with Prostaglandin E2. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 1 associated references with Prostaglandin E2. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 1 associated references with Prostaglandin E2. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C20H32O5
Mass 352.471
Synonyms Prostaglandin E2
Dinoprostone
PGE2
Prostin E2
Prepidil
363-24-6
Cervidil
Prostin
Dinoproston
Propess
Prostarmon E
Minprositin E2
Minprostin E2
Dinoprostonum
(15S)-Prostaglandin E2
l-Prostaglandin E2
Dinoprostona
Prepidil Gel
l-PGE2
Prostaglandin E2alpha
PubChem CID 5280360