Prostaglandin D2

Description

Description of prostaglandin D2 with associated disease summary

Prostaglandin D2 (PGD2) is an inflammatory mediator and can be detected by enzyme immunoassay (EIA) method. Concentration changes of prostaglandin D2 induced by allergen has been detected in various biologic samples including plasma, bronchoalveolar (BAL) fluid, nasal washing fluid, induced sputum and urine (J Allergy Clin Immunol. (2008)). The concentration levels of EBC PGD2 in asthma patients is increased after allergen inhalation (J Allergy Clin Immunol. (2008)). Description of disease(s) related to Prostaglandin D2 (PGD2):

Disease summary

Asthma

The EBC PGD2 concentrations in asthma patients increased after allergen inhalation (J Allergy Clin Immunol. (2008)).

Summary of extracted biomedical information

Associated references with human 5

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
Biomarker Profiles in Asthma With High vs Low Airway Reversibility and Poor Disease Control.	Chest	2015	WW. Busse, ST. Holgate, SW. Wenzel, P. Klekotka, Y. Chon, J. Feng, EP. Ingenito, A. Nirula Chest 2015 Dec;148(6):1489-1496. PubMed:26226215
Prostaglandin D₂ pathway upregulation: relation to asthma severity, control, and TH2 inflammation.	J. Allergy Clin. Immunol.	2013	ML. Fajt, SL. Gelhaus, B. Freeman, CE. Uvalle, JB. Trudeau, F. Holguin, SE. Wenzel J. Allergy Clin. Immunol. 2013 Jun;131(6):1504-12. PubMed:23506843
Lipid metabolite levels of prostaglandin D2 and eicosapentaenoic acid recovered from bronchoalveolar lavage fluid correlate with lung function of chronic obstructive pulmonary disease patients and controls.	Electrophoresis	2009	E. Csanky, R. Rühl, B. Scholtz, A. Vasko, L. Takacs, WM. Hempel Electrophoresis 2009 Apr;30(7):1228-34. PubMed:19294692
Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction.	J. Allergy Clin. Immunol.	1992	H. Magnussen, S. Boerger, K. Templin, AR. Baunack J. Allergy Clin. Immunol. 1992 Jun;89(6):1119-26. PubMed:1535083
Nasal challenge with cold, dry air results in release of inflammatory mediators. Possible mast cell involvement.	J. Clin. Invest.	1985	AG. Togias, RM. Naclerio, D. Proud, JE. Fish, NF. Adkinson, A. Kagey-Sobotka, PS. Norman, LM. Lichtenstein J. Clin. Invest. 1985 Oct;76(4):1375-81. PubMed:2414318

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to prostaglandin D2 is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 5 associated references with prostaglandin D2. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 5 associated references with prostaglandin D2. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 5 associated references with prostaglandin D2. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 5 associated references with prostaglandin D2. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₂₀H₃₂O₅
Mass	352.471
Synonyms	prostaglandin D2 PGD2 11-Dehydroprostaglandin F2-alpha 41598-07-6 11-Dehydroprostaglandin F2alpha BRN 2170623 [3H]PGD2 CHEBI:15555 (5Z,13E,15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate 9S,15S-dihydroxy-11-oxo-5Z,13E-prostadienoic acid (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate Prosta-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9-alpha,13E,15S)- (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid UNII-RXY07S6CZ2 (5z,13e)-(15s)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate 11-Dehydroprostaglandin F2 alpha [3H]prostaglandin D2 AC1L9LZD RXY07S6CZ2 BSPBio_001486
PubChem CID	448457