Zinc

Description

Description of Zinc with associated disease summary

Zinc is one of the metal indicators of interstitial lung diseases including sarcoidosis. Lower levels of zinc were detected in interstitial lung diseases patients. The depletion of zinc involved in the oxidant/anti-oxidant balance may be linked to the oxidative stress and chronic inflammation (J Breath Res. (2009)) In addition, higher zinc levels in lang=EN-US cystic fibrosis patients were detected compare with healthy control (J Cyst Fibros. (2003)). Description of disease(s) related to zinc:

Sarcoidosis

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect zinc and shows that the EBC zinc level in sarcoidosis patients are lower than the healthy controls (p < 0.05 versus controls) (J Breath Res. (2009)).

Cystic fibrosis

One study using inductive coupled plasma mass spectrometry (ICP-MS) to detect zinc and shows that the EBC zinc level in cystic fibrosis patients are the twice as the level in the healthy controls (p = 0.0193 versus controls) (J Cyst Fibros. (2003)).

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Zinc is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Cystic Fibrosis	MeSH: Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Year introduced: 1967 Link to MeSH Database: D003550	20
Sarcoidosis	MeSH: Sarcoidosis An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Year introduced: PSEUDOTUBERCULOSIS use SARCOIDOSIS 1963-1992 Link to MeSH Database: D012507	4

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with Zinc. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with Zinc. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with Zinc. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with Zinc. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	Zn
Mass	65.38
Synonyms	ZINC 7440-66-6 Zinc dust Zinc powder cinc Merrillite Rheinzink Jasad Blue powder Granular zinc Zinc, elemental Emanay zinc dust Asarco L 15 Zinc (fume or dust) zincum Zinc, ion (Zn1+) Zink Lead refinery vacuum zinc Zinc(1+) Zinc(1-)
PubChem CID	23994