Molybdenum

Description

Description of Molybdenum with associated disease summary

According to epidemiological data, environmental and occupational agents play a critical role in the development of interstitial lung diseases (ILDs), such as idiopathic interstitial pneumonia (IIPs), non-specific interstitial pneumonia (NSIP) and sarcoidosis. A study investigated the exhaled breath condensate (EBC) of 33 healthy subjects, 22 patients with sarcoidosis, 15 patients with NSIP and 19 with IIPs to determine the role of molybdenum (Mo) in the pathogenesis of ILDs. Mo traces were measured by inductively coupled plasma-mass spectrometry (ICP-MS). The report indicates Mo levels were below the limit of detection (LOD) in more than 50% of IPF cases, but detectable in NSIP, sarcoidosis, and control cases. IPF patients have lower Mo levels compared to controls. This reduction in Mo was possibly due to pulmonary depletion as a result of chronic oxidative stress and inflammation. Chronic inflammation and oxidative stress are important mechanisms in the pathogenesis of ILDs. Assessing the elemental composition of EBC in ILD patients seems to provide useful information, although further studies are required to confirm the robustness of this approach, and to better understand the underlying pathophysiological processes of ILDs. (J Breath Res. (2009) ) Description of disease(s) related to molybdenum

Idiopathic Pulmonary Fibrosis (IPF)

The report indicates Mo levels were below the limit of detection (LOD) in more than 50% of IPF cases, but detectable in NSIP, sarcoidosis, and control cases (J Breath Res. (2009)).

Non-specific interstitial pneumonia (NSIP)

No significant difference of iron level between NSIP patients and healthy control (J Breath Res. (2009)).

Sarcoidosis

No significant difference of iron level between sarcoidosis patients and healthy control (J Breath Res. (2009)).

Summary of extracted biomedical information

The involved biomedical functions are known as Mo-molybdopterin cofactor biosynthesis and Regulation. The associated genes/proteins with Molybdenum are LacZ Genes. Molybdenum is associated with cofactor and Nitrate.

Associated references with human 1

Download references

Reference title with link to reference page	Journal	Year	Authors & PubMed Link
Hard-rock mining exposures affect smokers and nonsmokers differently. Results of a community prevalence study.	Am. Rev. Respir. Dis.	1989	K. Kreiss, LM. Greenberg, SJ. Kogut, DC. Lezotte, CG. Irvin, RM. Cherniack Am. Rev. Respir. Dis. 1989 Jun;139(6):1487-93. PubMed:2786363

Associated curated diseases 1

Download diseases

Associated disease mapping

Mapping of all associated diseases to Molybdenum is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Idiopathic Pulmonary Fibrosis	MeSH: Idiopathic Pulmonary Fibrosis A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change. Year introduced: 2009 Link to MeSH Database: D054990	3

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 1 associated references with Molybdenum. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 1 associated references with Molybdenum. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 1 associated references with Molybdenum. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 1 associated references with Molybdenum. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	Mo
Mass	95.95
Synonyms	MOLYBDENUM 7439-98-7 Molybdenum(6+) Molybdenum, elemental Molybdenum(6+) ion MChVL MOLYBDENUM(VI) ION Molybdenum, metallic Metco 63 MOLYBDENUM ATOM Molybdenum, ion (Mo(6+)) TsM1 Amperit 106.2 Amperit 105.054 (99mo)molybdenum MO Molybdenum (VI) ion UNII-81AH48963U HSDB 5032 EINECS 231-107-2
PubChem CID	23932