Neopterin

Description

Description of neopterin with associated disease summary

Neopterin is a marker of immune response and can be detected by enzyme immunoassay (EIA) method. In serum, it increased in viral infections patients. In urine, it is an indicator of sepsis severity. Study by Warwick G et al. shows that the sputum neopterin is increased in people with the symptoms of a viral infection. However, no significant difference in EBC neopterin between people with and without the viral infection (Respirology. (2013)). Description of disease(s) related to Neopterin:

Disease summary

Asthma

The sputum neopterin is increased in asthma patients with the symptoms of a viral infection. However, no significant difference in EBC neopterin between asthma patients with and without the viral infection (Respirology. (2013)).

Chronic obstructive pulmonary disease (COPD)

The sputum neopterin is increased in COPD patients with the symptoms of a viral infection. However, no significant difference in EBC neopterin between COPD patients with and without the viral infection (Respirology. (2013)).

Summary of extracted biomedical information

Neopterin is associated with abnormalities such as Cardiovascular morbidity, Central obesity, Atherosclerosis, Senile Plaques and Acute coronary syndrome. The involved biomedical functions are known as Macrophage Activation, Sleep Fragmentation, Hypoxia, Pathogenesis and Cardiac Death. The associated genes/proteins with neopterin are Thrombogen.
Imgsrv

Associated references with human 3

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Reference title

with link to reference page

Journal Year Authors & PubMed Link
Antioxidant and inflammatory biomarkers for the identification of prodromal Parkinson's disease. J. Neurol. Sci. 2016 J. Campolo, R. De Maria, L. Cozzi, M. Parolini, S. Bernardi, P. Proserpio, L. Nobili, G. Gelosa, I. Piccolo, EC. Agostoni, MG. Trivella, P. Marraccini
J. Neurol. Sci. 2016 Nov;370:167-172. PubMed:27772753
Measurement of neopterin, TGF-β1 and ACE in the exhaled breath condensate of patients with sarcoidosis. J Breath Res 2013 H. Ahmadzai, B. Cameron, J. Chui, A. Lloyd, D. Wakefield, PS. Thomas
J Breath Res 2013 Dec;7(4):046003. PubMed:24091835
Elevated levels of neopterin in sleep-disordered breathing. Chest 2007 NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko
Chest 2007 Oct;132(4):1124-30. PubMed:17646222

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to neopterin is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 13

Concept Name External ID Weighted Score Hits References
Cardiovascular morbidity 950.5 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Central obesity 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Atherosclerosis ICD9-CM:440 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Senile Plaques 672.14 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Acute coronary syndrome 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Unstable angina ICD9-CM:411.1 925.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Acute myocardial infarction ICD9-CM:410.9 961.5 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
chronic stable angina 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Kidney Failure ICD9-CM:586 964.29 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Autoimmune Diseases 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Systemic infection ICD9-CM:995.91 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Cardiovascular Diseases ICD9-CM:429.2 978.26 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest
Obesity 1000.0 1
  1. Elevated levels of neopterin in sleep-disordered breathing.
    NM. Punjabi, BA. Beamer, A. Jain, ME. Spencer, N. Fedarko (2007) Chest

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 3 associated references with neopterin. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 3 associated references with neopterin. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 3 associated references with neopterin. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C9H11N5O4
Mass 253.218
Synonyms neopterin
Monapterin
670-65-5
neopterine
2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone
AC1Q6INQ
AC1L1I7D
SCHEMBL2304401
[S-(R*,S*)]-2-Amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-on
[S-(R*,S*)]-2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridine-4-one
SCHEMBL11301495
CTK8H6981
HMDB00845
4(1H)-Pteridinone, 2-amino-6-(1,2,3-trihydroxypropyl)-
AR-1J6824
NSC614990
ZINC03873279
AKOS022507201
MCULE-4858540073
NSC-614990
PubChem CID 4455