N,N-Dibutylformamide

Description

Description of N,N-Dibutylformamide with associated disease summary

Certain individuals are susceptible to high altitude pulmonary edema (HAPE); the ability to identify individuals at risk of HAPE is currently very poor. Analysis of exhaled breath condensate (EBC) may present a favorable non-invasive method. A study examined the profile of volatile organic compounds (VOC) in EBC of healthy males with/without a history of HAPE. This study used auto-regression, partial least square regression of whole GC/MS data, and binary logistic regression (BLR) of individual GC peaks. This resulted in variable success. The N,N-dibutylformamide compound can be formed in radical reactions from urea or uric acid, or from degradation of larger molecules. The peak for N,N-dibutylformamide was identified, and the study suggests it may be a potential discriminatory marker for patients with HAPE history. Further studies are needed to establish mechanistic details of formation and biological basis for the detected biomarker compounds. The results presented here, however, are consistent with possible alteration of oxidative chemistry in HAPE subjects during hypoxia events. ( J Breath Res. (2015) ) Description of disease(s) related to Formamide, N,N-dibutyl-:

Disease summary

High altitude pulmonary edema (HAPE) | High altitude pulmonary oedema (HAPO)

The N,N-dibutylformamide compound can be formed in radical reactions from urea or uric acid, or from degradation of larger molecules. The peak for N,N-dibutylformamide was identified, and the study suggests it may be a potential discriminatory marker for patients with HAPE history. Further studies are needed to establish mechanistic details of formation and biological basis for the detected biomarker compounds ( J Breath Res. (2015) ).

Summary of extracted biomedical information

Associated references with human 0

Download references
Reference title

with link to reference page

Journal Year Authors & PubMed Link

Associated curated diseases 2

Download diseases

Associated disease mapping

Mapping of all associated diseases to N,N-Dibutylformamide is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Acute Mountain Sickness MeSH: Altitude Sickness
Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975)
Link to MeSH Database: D000532
2
Idiopathic Pulmonary Arterial Hypertenion MeSH: Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Link to MeSH Database: D006976
1

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with N,N-Dibutylformamide. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with N,N-Dibutylformamide. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with N,N-Dibutylformamide. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with N,N-Dibutylformamide. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C9H19NO
Mass 157.257
Synonyms N,N-DIBUTYLFORMAMIDE
761-65-9
Dibutylformamide
Formamide, N,N-dibutyl-
N,N-Di-n-butylformamide
Formamide, N,N-di-n-butyl-
Dibutylamid kyseliny mravenci
EINECS 212-090-0
Dibutylamid kyseliny mravenci [Czech]
NSC 404525
BRN 0636100
AI3-18810
NZMAJUHVSZBJHL-UHFFFAOYSA-N
AK163260
W-104375
UNII-4315805S5N
formamide, dibutyl-
N-Formyldibutylamine
Formamide,N-dibutyl-
N,N-Di-butylformamide
PubChem CID 12975