Quinolinic acid

Description

Description of quinolinic acid with associated disease summary

Quinolinic acid is a potential biomarker of asthma. To detect and quantify acetate, LC-MS/MS method is applied. One study hypothesized that the pulmonary tryptophan-catabolising enzyme indoleamine 2,3-dioxygenase (IDO) inhibited by Th4 cytokines is impaired in allergic asthma patients according to the Th4 cytokine profiles in asthma patients (Thorax. (2013)). In addition, this study attempted to find the relation between the rhinovirus infection and IDO because allergic asthma is frequently caused by rhinovirus infection (Thorax. (2013)). The downstream product of IDO including quinolinic acid and kynurenine were decreased in asthma patients. This result supports the first hypothesis that the pulmonary IDO activity is impaired in patients. However, low-dose rhinovirus infection did not change the IDO activities in both healthy controls and asthma patients (Thorax. (2013)). Description of disease(s) related to quinolinic acid:

Asthma

The concentrations of EBC quinolinic acid decreased in asthma patients (Thorax. (2013)) compared with healthy control. This result supports the hypothesis that the pulmonary IDO activities are impaired in patients (Thorax. (2013)). However, the rhinovirus infection which is linked to the asthma cannot change the pulmonary IDO activities in patients.

Summary of extracted biomedical information

Associated references with human 0

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Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to quinolinic acid is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with quinolinic acid. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with quinolinic acid. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with quinolinic acid. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with quinolinic acid. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C7H5NO4
Mass 167.12
Synonyms quinolinic acid
2,3-pyridinedicarboxylic acid
Pyridine-2,3-dicarboxylic acid
89-00-9
quinolinate
Pyridine-2,3-dicarboxylate
AI3-63017
2,3-pyridindicarbons
pyridinedicarboxylic acid
EINECS 201-874-8
pyridine-2,3-carboxylate
NSC 13127
2,3-PyridinedicarboxylicAcid
CHEMBL286204
CHEBI:16675
GJAWHXHKYYXBSV-UHFFFAOYSA-N
339155-13-4
AK-50219
AC-907/25014157
Q-201654
PubChem CID 1066