1,3-Benzothiazole

Description

Description of 1,3-Benzothiazole with associated disease summary

Early diagnosis and treatment of pulmonary arterial hypertension (PAH) may be made possible by the exploration of novel quantifiable biomarkers. Exhaled breath condensate (EBC) from 30-age-matched normal healthy individuals and 27 idiopathic pulmonary arterial hypertension (IPAH; New York Heart Association functional class III/IV) patients were collected. EBC samples were analyzed using gas chromatography/mass spectrometry (GC-MS) followed by autoregression, and partial least squares regression (AR/PLSR) analysis to discriminate between the IPAH and control groups. Benzothiazole is present in IPAH samples with high confidence. Overall, it was observed that EBC in IPAH patients appear to be more oxidized than control groups. Benzothiazole could be a potential biomarker for early diagnosis of IPAH pulmonary hemodynamics ( PLoS One. (2014) ). Description of disease(s) related to Benzothiazole:

Disease summary

Idiopathic pulmonary arterial hypertension (IPAH)

Benzothiazole is present in IPAH samples with high confidence. Overall, it was observed that EBC in IPAH patients appear to be more oxidized than control groups ( PLoS One. (2014) ).

Summary of extracted biomedical information

1,3-benzothiazole is associated with abnormalities such as Acquired Immunodeficiency Syndrome. The involved biomedical functions are known as Irritation and volatile substances. 1,3-benzothiazole is associated with benzothiazole, Naphthalene, Nitrogen, Amides and Organic acid.

Associated references with human 5

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Reference title

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Journal Year Authors & PubMed Link
Detection and Quantification of Benzothiazoles in Exhaled Breath and Exhaled Breath Condensate by Real-Time Secondary Electrospray Ionization-High-Resolution Mass Spectrometry and Ultra-High Performance Liquid Chromatography. Environ. Sci. Technol. 2015 D. García-Gómez, L. Bregy, Y. Nussbaumer-Ochsner, T. Gaisl, M. Kohler, R. Zenobi
Environ. Sci. Technol. 2015 Oct;49(20):12519-24. PubMed:26390299
A review of the volatiles from the healthy human body. J Breath Res 2014 B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe
J Breath Res 2014 Mar;8(1):014001. PubMed:24421258
Human health risk assessment of synthetic turf fields based upon investigation of five fields in Connecticut. J. Toxicol. Environ. Health Part A 2011 G. Ginsberg, B. Toal, N. Simcox, A. Bracker, B. Golembiewski, T. Kurland, C. Hedman
J. Toxicol. Environ. Health Part A 2011 ;74(17):1150-74. PubMed:21797769
Alignment of retention time obtained from multicapillary column gas chromatography used for VOC analysis with ion mobility spectrometry. Anal Bioanal Chem 2010 T. Perl, B. Bödeker, M. Jünger, J. Nolte, W. Vautz
Anal Bioanal Chem 2010 Jul;397(6):2385-94. PubMed:20512565
Assessment of occupational health hazards in scrap-tire shredding facilities. Sci. Total Environ. 2003 YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu
Sci. Total Environ. 2003 Jun;309(1-3):35-46. PubMed:12798090

Associated curated diseases 4

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Associated disease mapping

Mapping of all associated diseases to 1,3-Benzothiazole is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

with link to disease page

Description of MeSH term

with link to MeSH Database

Number of references
Idiopathic Pulmonary Arterial Hypertenion MeSH: Hypertension, Pulmonary
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Link to MeSH Database: D006976
1
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31
Bronchiectasis MeSH: Bronchiectasis
Persistent abnormal dilatation of the bronchi.
Link to MeSH Database: D001987
3
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249
91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 5 associated references with 1,3-Benzothiazole. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 13

Concept Name External ID Definition Weighted Score Hits References
Naphthalene CHEBI:16482 965.25 2
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
  2. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere
benzothiazole 991.35 2
  1. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere
Naphthalenes 1000.0 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
undecane 1000.0 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
decane 1000.0 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
octane 930.5 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
benzothiazole-2-sulfonic acid 885.5 1
  1. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere
Toluene CHEBI:17578 1000.0 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
2-methylnaphthalene 1000.0 1
  1. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere
1-methylnaphthalene 1000.0 1
  1. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere
Polycyclic Hydrocarbons, Aromatic CHEBI:33848 764.23 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
Carbon Black 1000.0 1
  1. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere
asphalt 895.0 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.

Associated functions 2

Concept Name External ID Definition Weighted Score Hits References
Irritation 944.0 1
  1. Assessment of occupational health hazards in scrap-tire shredding facilities.
    YC. Chien, S. Ton, MH. Lee, T. Chia, HY. Shu, YS. Wu (2003) Sci. Total Environ.
volatile substances 859.37 1
  1. Characterization of substances released from crumb rubber material used on artificial turf fields.
    X. Li, W. Berger, C. Musante, MI. Mattina (2010) Chemosphere

Associated genes 0

No associated genes are detected in current reference collection.

There are 5 associated references with 1,3-Benzothiazole. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C7H5NS
Mass 135.184
Synonyms BENZOTHIAZOLE
95-16-9
BENZO[D]THIAZOLE
1,3-Benzothiazole
Benzosulfonazole
1-Thia-3-azaindene
Vangard BT
benzothiazol
USAF EK-4812
benzthiazole
CHEBI:45993
FEMA Number 3256
UNII-G5BW2593EP
O-2857
FEMA No. 3256
CCRIS 7893
HSDB 2796
NSC 8040
EINECS 202-396-2
BRN 0109468
PubChem CID 7222