14,15-LTD4

Description

Description of 14,15-LTD4 with associated disease summary

14,15-leukotriene D4 is renamed eoxin D4 recently. It resemble cysteinyl leukotrienes, but has different 3D structure. Eoxin D4 is involved in 15-lipoxygenase pathway with proinflammatory activities. EBC eoxin D4 level is reported to elevate significantly in children with asthma or bronchial hyperresponsiveness (BHR), compared to healthy children. Significant association between eoxin D4 value in EBC and asthma is demonstrated. EBC from children with asthma show significantly higher eoxin D4 level versus other chronic lung diseases (J Allergy Clin Immunol. (2011)). In study of adults, there is no difference in EBC levels between patients with asthma and healthy controls. However, eoxin D4 concentration in EBC in aspirin-induced asthma subjects is significantly higher than one in aspirin tolerance asthma subjects. Within patients with aspirin tolerance asthma, elevated level of EBC eoxin D4 is shown in females. No correlation of atopy status and eoxin D4 level is observed (J Allergy Clin Immunol. (2010)). Eoxin D4 in EBC is identified using HPLC-MS/MS in both studies. Description of disease(s) related to 14,15-leukotrienes D4:

Asthma

Higher concentrations of eoxin D4 in EBC are observed in children with asthma, but in adults, no difference of EBC D4 level is observed in asthma subjects.

Aspirin-induced asthma

EBC eoxin D4 values are significantly higher in aspirin-induced asthma subjects than ones in aspirin-tolerant subjects. Females with aspirin-induced asthma show elevated level of eoxin D4 in EBC.

Summary of extracted biomedical information

Associated references with human 0

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to 14,15-LTD4 is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Asthma	MeSH: Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL). Link to MeSH Database: D001249	91
Aspirin Sensitive Asthma	MeSH: Asthma, Aspirin-Induced Asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use. Year introduced: 2010 Link to MeSH Database: D055963	2

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 14,15-LTD4. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 14,15-LTD4. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 14,15-LTD4. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 14,15-LTD4. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₂₅H₄₀N₂O₆S
Mass	496.663
Synonyms	EXD4 14,15-Leukotriene D4 14,15-LTD4 15S-hydroxy,14R-(S-cysteinylglycinyl)-5Z,8Z,10E,12E-eicosatetraenoic acid eoxin D4 CHEBI:63985 LMFA03020032 S-[(1R,2E,4E,6Z,9Z)-1-[(S)-1-Hydroxyhexyl]-13-carboxy-2,4,6,9-tridecatetraenyl]-Cys-Gly-OH S-[(6S,7R,8E,10E,12Z,15Z)-19-carboxy-6-hydroxynonadeca-8,10,12,15-tetraen-7-yl]-L-cysteinylglycine
PubChem CID	42607304