12-Hydroxyeicosapentaenoate

Description

Description of 12-Hydroxyeicosapentaenoate with associated disease summary

12-hydroxyeicosapentaenoic acid (12-HEPE) is an eicosapentanoic acid (EPA) bioactive metabolite and pathway marker. It is one of specialized proresolving mediators (SPMs), which play a critical role in the active resolution of inflammation without immunosuppression. 12-HEPE values in EBC are shown to decrease in chronic obstructive pulmonary disease (COPD) subjects compared to healthy controls. The concentration of EBC 12-HEPE is identified using lipid-mediator metabolipidomics by matching criteria and MS/MS spectra (Am J Physiol Lung Cell Mol Physiol. (2015)). Description of disease(s) related to 12-hydroxyeicosapentaenoic acid (12-HEPE):

Chronic obstructive pulmonary disease (COPD)

12-HEPE level in EBC drops in patients with COPD relative to healthy controls.

Summary of extracted biomedical information

Imgsrv

Associated references with human 0

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Reference title

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Journal Year Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to 12-Hydroxyeicosapentaenoate is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Chronic Obstructive Pulmonary Disease (Copd) MeSH: Pulmonary Disease, Chronic Obstructive
A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA. Year introduced: 2002
Link to MeSH Database: D029424
31

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 12-Hydroxyeicosapentaenoate. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 12-Hydroxyeicosapentaenoate. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 12-Hydroxyeicosapentaenoate. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 12-Hydroxyeicosapentaenoate. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C20H30O3
Mass 318.457
Synonyms (+/-)-12-hydroxy-5Z,8Z,10E,14Z,17Z-eicosapentaenoic acid
81187-21-5
12-HEPE
12-Hydroxyeicosapentaenoic acid
(+/-)-12-HEPE
(+/-)12-HEPE
12-hydroxyicosa-(5Z,8Z,10E,14Z,17Z)-pentaenoic acid
12-Hydroxyeicosapentaenoate
SCHEMBL12970718
HMDB10202
12-Hepe, (+/-)-
1022AH
LMFA03070031
CC-00122
12-Hydroxy-5,8,10,14,17-eicosapentaenoate
12-Hydroxy-5,8,10,14,17-eicosapentaenoic acid
12-hydroxyicosa-(5Z,8Z,10E,14Z,17Z)-pentaenoate
(5Z,8Z,10E,14Z,17Z)-12-Hydroxy-5,8,10,14,17-eicosapentaenoic acid
(5Z,8Z,10E,14Z,17Z)-12-Hydroxy-5,8,10,14,17-icosapentaenoic acid
PubChem CID 10041593