4-Hydroxynonenal

Description

Description of 4-Hydroxynonenal with associated disease summary

4-hydroxynonenal (4-HNE) is a known oxidative stress biomarker. They are formed endogenously by lipid peroxidation in situ and released into the extracellular space. EBC 4-HNE levels were reported to be increased in patients with occupational lung diseases. Long-term exposure to silicosis or asbestos dust induce a generation of reactive oxygen species including 4-HNE in the lung. In this study, quantification of EBC 4-HNE was achieved by a solid-phase extraction (SPE), followed by a LC-ESI-MS/MS detection with the selected reaction monitoring (SRM) mode. ( Chromatogr B.(2009) ) EBC 4-HNE detection was found to be a promising non-invasive tool for the evaluation of activity of both silica and asbestos-induced diseases. This may expands diagnostic potential to oxidative stress inducing occupational lung diseases. Description of disease(s) related to 4-hydroxynonenal (4-HNE):

Occupational lung diseases

Significant increase in the concentration of EBC 4-HNE of patients suffering occupational lung diseases

Summary of extracted biomedical information

Imgsrv

Associated references with human 0

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Reference title

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Journal Year Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to 4-Hydroxynonenal is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Occupational Respiratory Diseases MeSH: Respiration Disorders
Diseases of the respiratory system in general or unspecified or for a specific respiratory disease not available. Year introduced: 1977
Link to MeSH Database: D012120
1

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 4-Hydroxynonenal. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 4-Hydroxynonenal. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 4-Hydroxynonenal. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 4-Hydroxynonenal. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C9H16O2
Mass 156.225
Synonyms 4-Hydroxynonenal
4-Hydroxy-2-nonenal
4-hydroxynon-2-enal
trans-4-Hydroxy-2-nonenal
4-Hydroxy-2,3-nonenal
4-HNE
4-hydroxy-2E-nonenal
CCRIS 1781
CCRIS 9028
2-NONENAL, 4-HYDROXY-
128946-65-6
(E)-4-hydroxy-2-nonenal
(E)-4-hydroxynon-2-enal
(2E)-4-hydroxynon-2-enal
CHEMBL454280
75899-68-2
HNE
CHEBI:58968
C9H16O2
(+/-)4-HYDROXYNON-2-ENAL
PubChem CID 5283344