11-trans-LTC4

Description

Description of 11-trans-LTC4 with associated disease summary

A recent study aimed to compare the content and profile of a wider range of eicosanoids in the exhaled breath condensate (EBC) obtained from patients and a healthy subjects. 11-trans-Leukotriene C4 is one of the known eicosanoids. Samples from 33 children (aged 12.4+-3.1 years) with stable atopic asthma and 25 healthy controls (11.8 +-3.2 years) were collected. The analysis shows 11-trans-Leukotriene C4 level was significantly higher in asthmatics compared to healthy children ( Pediatr Pulmonol. (2013) ). Description of disease(s) related to 11-trans-Leukotriene C4:

Disease summary

Asthma

The analysis shows 11-trans-Leukotriene C4 level was significantly higher in asthmatics compared to healthy children ( Pediatr Pulmonol. (2013) ).

Summary of extracted biomedical information

Associated references with human 0

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Reference title

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Journal Year Authors & PubMed Link

Associated curated diseases 1

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Associated disease mapping

Mapping of all associated diseases to 11-trans-LTC4 is displayed in red.

Heart Lung Airway Esophagus Kidney Intestine
Disease Name

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Description of MeSH term

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Number of references
Asthma MeSH: Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Link to MeSH Database: D001249 		91

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 0 associated references with 11-trans-LTC4. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 0 associated references with 11-trans-LTC4. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 0 associated references with 11-trans-LTC4. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 0 associated references with 11-trans-LTC4. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

Chemical Information

Formula C30H47N3O9S
Mass 625.778
Synonyms 11-trans-Leukotriene C4
11-trans-LTC4
CHEBI:88515
5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11E14Z-eicosatetraenoic acid
5S-Hydroxy-6R-(S-glutathionyl)-7E,9E,11E,14Z-eicosatetraenoic acid
C30H47N3O9S
Leukotriene C2
cysteinyl leukotriene
AC1NR1LK
11-TRANSLEUKOTRIENEC4
CHEMBL445208
HMDB05095
1460AH
LMFA03020020
ZINC40164471
5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11E14Z-eicosatetraenoate
(5S,6R,7E,9E,11E,14Z)-6-[(2R)-2-[[(4S)-4-amino-5-hydroxy-5-oxopentanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
[R-[R*,S*-(E,E,E,Z)]]-N-[S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-L-g-glutamyl-L-cysteinyl]-Glycine
[R-[R*,S*-(E,E,E,Z)]]-N-[S-[1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl]-N-L-gamma-glutamyl-L-cysteinyl]-Glycine
PubChem CID 5283134