Campholenic aldehyde

Description

Description of Campholenic aldehyde with associated disease summary

Certain individuals are susceptible to high altitude pulmonary edema (HAPE); the ability to identify individuals at risk of HAPE is currently very poor. Analysis of exhaled breath condensate (EBC) may present a favorable non-invasive method. A study examined the profile of volatile organic compounds (VOC) in EBC of healthy males with/without a history of HAPE. This study used auto-regression, partial least square regression of whole GC/MS data, and binary logistic regression (BLR) of individual GC peaks. This resulted in variable success. The peak for campholene aldehyde was identified, but its significance or its role in HAPE is unclear. Further studies are needed to establish mechanistic details of formation and biological basis for the detected biomarker compounds. The results presented here, however, are consistent with possible alteration of oxidative chemistry in HAPE subjects during hypoxia events ( J Breath Res. (2015) ). Description of disease(s) related to campholene aldehyde:

Disease summary

High altitude pulmonary edema (HAPE) | High altitude pulmonary oedema (HAPO)

The peak for campholene aldehyde was identified, but its significance or its role in HAPE is unclear. Further studies are needed to establish mechanistic details of formation and biological basis for the detected biomarker compounds. The results presented here, however, are consistent with possible alteration of oxidative chemistry in HAPE subjects during hypoxia events ( J Breath Res. (2015) )

Summary of extracted biomedical information

Associated references with human 1

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Reference title with link to reference page	Journal	Year	Authors & PubMed Link
A review of the volatiles from the healthy human body.	J Breath Res	2014	B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne, NM. Ratcliffe J Breath Res 2014 Mar;8(1):014001. PubMed:24421258

Associated curated diseases 2

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Associated disease mapping

Mapping of all associated diseases to Campholenic aldehyde is displayed in red.

Disease Name with link to disease page	Description of MeSH term with link to MeSH Database	Number of references
Acute Mountain Sickness	MeSH: Altitude Sickness Multiple symptoms associated with reduced oxygen at high ALTITUDE. Year introduced: 1991(1975) Link to MeSH Database: D000532	2
Idiopathic Pulmonary Arterial Hypertenion	MeSH: Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. Link to MeSH Database: D006976	1

Associated abnormalities 0

No associated abnormalities are detected in current reference collection.

There are 1 associated references with Campholenic aldehyde. Due to lack of full text of references or no associated abnormalities are detected in our text-mining workflow, we cannot extract any abnormality terms from the associated reference collection.

Associated chemicals 0

No associated chemicals are detected in current reference collection.

There are 1 associated references with Campholenic aldehyde. Due to lack of full text of references or no associated chemicals are detected in our text-mining workflow, we cannot extract any chemical terms from the associated reference collection.

Associated functions 0

No associated functions are detected in current reference collection.

There are 1 associated references with Campholenic aldehyde. Due to lack of full text of references or no associated functions are detected in our text-mining workflow, we cannot extract any function terms from the associated reference collection.

Associated genes 0

No associated genes are detected in current reference collection.

There are 1 associated references with Campholenic aldehyde. Due to lack of full text of references or no associated genes are detected in our text-mining workflow, we cannot extract any gene terms from the associated reference collection.

NCBI Entrez Crosslinks

Chemical Information

Formula	C₁₀H₁₆O
Mass	152.237
Synonyms	Campholenic aldehyde alpha-Campholenic aldehyde .alpha.-Campholenal 91819-58-8 .alpha.-Campholene aldehyde 2-(2,2,3-trimethylcyclopent-3-en-1-yl)acetaldehyde .alpha.-Campholenaldehyde 2,2,3-Trimethyl-3-cyclopenten-1-acetaldehyde .alpha.-Campholenic aldehyde OGCGGWYLHSJRFY-UHFFFAOYSA-N (2,2,3-Trimethyl-cyclopent-3-enyl)-acetaldehyde (2,2,3-trimethylcyclopent-3-en-1-yl)acetaldehyde 4501-58-0 alpha-Campholenaldehyde W-106167 2-(2,2,3-trimethyl-1-cyclopent-3-enyl)acetaldehyde Campholenaldehyde 3-Cyclopentene-1-acetaldehyde, 2,2,3-trimethyl- 2,3-Trimethyl-3-cyclopentacetaldehyde 3-Cyclopentene-1-acetaldehyde, 2,2,3-trimethyl-, (1R)-
PubChem CID	98497